{"id":"W3128144765","doi":"10.1101/2021.02.07.430165","title":"Loss of PABPC1 is compensated by elevated PABPC4 and correlates with transcriptome changes","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Canadian Institutes of Health Research","keywords":"Gene isoform; Polyadenylation; Transcriptome; HEK 293 cells; Biology; Cell biology; Translation (biology); Poly(A)-binding protein; Messenger RNA; Molecular biology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001136717,0.0003676866,0.0004068885,0.0004193838,0.0002804015,0.0005217892,0.0002717387,0.0003833256,0.0030883],"category_scores_gemma":[0.000157637,0.0002074641,0.0003328869,0.0003146995,0.0003222573,0.0002078377,0.0004352717,0.001253989,0.001466688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004278449,"about_ca_system_score_gemma":0.0002784703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009844702,"about_ca_topic_score_gemma":0.0008750165,"domain_scores_codex":[0.9997008,0.00002014733,0.0000164302,0.00009764326,0.00009508384,0.00006987945],"domain_scores_gemma":[0.9997193,0.00003665569,0.00008572794,0.00003870874,0.00003237205,0.00008725079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005625231,0.000008218432,0.0002517097,0.00001385423,0.000003180446,0.00007538309,0.00000544153,0.00004272313,0.9988907,0.00005628906,0.00009111878,0.0005050965],"study_design_scores_gemma":[0.000006752862,0.00002822483,0.01611323,0.000005594988,0.00001005013,0.0004346056,0.00003987714,0.001078345,0.978801,0.0001072153,0.003367188,0.000007965775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768404,0.001533369,0.01036958,0.0003683699,0.0001663278,0.00002150898,0.006497839,0.0008479164,0.003354736],"genre_scores_gemma":[0.9746612,0.0006080111,0.003646435,0.0001933286,0.00002496947,0.00004445431,0.005735721,0.0005437302,0.01454221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0030883,"threshold_uncertainty_score":0.01033139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006218045077493819,"score_gpt":0.2186767620210922,"score_spread":0.2124587169435984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}