{"id":"W3128155416","doi":"10.2139/ssrn.3766286","title":"Discovery and Validation of a 3-Gene Transcriptional Signature to Distinguish COVID-19 and Other Viral Infections from Bacterial Sepsis in Adults; A Case-Control then Observational Cohort Study","year":2021,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"COVID-19 diagnosis using AI","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity; Discovery Centre","funders":"Wellcome Trust","keywords":"Cohort; Medicine; Gene signature; Infection control; Cohort study; Viral load; Sepsis; Immunology; Receiver operating characteristic; Virology; Internal medicine; Gene; Biology; Gene expression; Intensive care medicine; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001637914,0.0004743926,0.0005082149,0.0007155427,0.0006696143,0.001290742,0.0005164815,0.0008087942,0.001250772],"category_scores_gemma":[0.002503803,0.0003882237,0.0009874932,0.0008095387,0.0005451764,0.0004909585,0.0006299023,0.000846974,0.0003601458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000369307,"about_ca_system_score_gemma":0.0005888728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002832236,"about_ca_topic_score_gemma":0.003733965,"domain_scores_codex":[0.9989414,0.00023296,0.00009206021,0.0003750834,0.0001688597,0.0001896914],"domain_scores_gemma":[0.9987444,0.0002606887,0.0003665701,0.0002329549,0.0001884198,0.0002069517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007216063,0.0001277426,0.9942102,0.00001521503,0.0001413805,0.0001547198,0.0001206013,0.00003066335,0.002883623,0.00005107564,0.0001362143,0.001406934],"study_design_scores_gemma":[0.00007415596,0.0005366003,0.9968514,0.00001155389,0.0001706439,0.0005591786,0.00032629,0.0004251401,0.000495014,0.00007741195,0.0004616377,0.00001085712],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986091,0.0001811872,0.0004798079,0.00003151464,0.0000144752,0.0000285049,0.0004658666,0.000003777688,0.0001857401],"genre_scores_gemma":[0.9986354,0.00006564322,0.0004490862,0.00005493266,0.00001499953,0.00002580089,0.0005931075,0.000005575185,0.0001555052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002832236,"threshold_uncertainty_score":0.008662283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02127439362595673,"score_gpt":0.3011512422596146,"score_spread":0.2798768486336579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}