{"id":"W3128155416","doi":"10.2139/ssrn.3766286","title":"Discovery and Validation of a 3-Gene Transcriptional Signature to Distinguish COVID-19 and Other Viral Infections from Bacterial Sepsis in Adults; A Case-Control then Observational Cohort Study","year":2021,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"COVID-19 diagnosis using AI","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity; Discovery Centre","funders":"Wellcome Trust","keywords":"Cohort; Medicine; Gene signature; Infection control; Cohort study; Viral load; Sepsis; Immunology; Receiver operating characteristic; Virology; Internal medicine; Gene; Biology; Gene expression; Intensive care medicine; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001006949,0.0001778448,0.0003769606,0.000186416,0.000153362,0.00007723278,0.0000529986,0.0001011218,0.0000986673],"category_scores_gemma":[0.001179935,0.0001683554,0.00008443588,0.0002730836,0.00005065661,0.0001997249,0.00002179099,0.0007485205,7.2603e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008816305,"about_ca_system_score_gemma":0.002692437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003071172,"about_ca_topic_score_gemma":0.009827432,"domain_scores_codex":[0.9980421,0.0002770774,0.0004448701,0.0003696666,0.0003407321,0.0005255202],"domain_scores_gemma":[0.9989191,0.0004662225,0.0001444061,0.0001477808,0.0001699812,0.0001524953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001047918,0.0008745316,0.9773962,0.00003795732,0.0005753352,0.0001760597,0.002505153,0.0003633353,0.01570423,0.0006750801,0.0000531062,0.0005911007],"study_design_scores_gemma":[0.01427738,0.001403888,0.9684806,0.0002337077,0.0008293521,0.00253678,0.003104729,0.0003569863,0.0005435021,0.006906005,0.0009911443,0.0003358965],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988806,0.0005589536,0.00375921,0.005847627,0.0001428841,0.0006488871,0.0002147154,0.00001501972,0.000006708209],"genre_scores_gemma":[0.9962704,0.00010701,0.0001700365,0.00284978,0.0004023869,0.00005132972,0.00007422711,0.00002366872,0.00005121941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01516073,"threshold_uncertainty_score":0.6865333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02127439362595673,"score_gpt":0.3011512422596146,"score_spread":0.2798768486336579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}