{"id":"W3128167085","doi":"10.2147/ijn.s290466","title":"Preparation, Characterization, Pharmacokinetic, and Therapeutic Potential of Novel 6-Mercaptopurine-Loaded Oral Nanomedicines for Acute Lymphoblastic Leukemia","year":2021,"lang":"en","type":"article","venue":"International Journal of Nanomedicine","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Science and Technology Major Project; Beijing Children's Hospital, Capital Medical University; Children's Health Research Institute","keywords":"Pharmacology; Pharmacokinetics; Bioavailability; In vivo; Jurkat cells; In vitro; Medicine; Materials science; Chemistry; Immunology; Biology; Biochemistry; Immune system; T cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004286033,0.0002326202,0.0007078409,0.0005016453,0.00004812871,0.00002790509,0.0002794176,0.000112802,0.0002441224],"category_scores_gemma":[0.0005001191,0.0001819711,0.0001756371,0.0003062604,0.0002852142,0.0001789461,0.00009096247,0.0001887282,0.000002012874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004798589,"about_ca_system_score_gemma":0.001820431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008870259,"about_ca_topic_score_gemma":7.772812e-7,"domain_scores_codex":[0.9971176,0.0000453546,0.001152765,0.0002718047,0.001149796,0.0002626569],"domain_scores_gemma":[0.994866,0.0002555479,0.0006912114,0.000181044,0.003753817,0.0002524511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003440866,0.0003731367,0.001252895,0.0001156773,0.001974538,0.000355055,0.0003011707,0.0001218066,0.9845721,0.0001607448,0.0006690092,0.006662965],"study_design_scores_gemma":[0.117864,0.00690507,0.1275208,0.002550703,0.005602711,0.03246245,0.0007063698,0.0679312,0.6068225,0.0003670248,0.03051322,0.0007539346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.925896,0.0008288983,0.06469324,0.006522357,0.001503869,0.0003765576,0.0001017792,0.00001496289,0.00006230287],"genre_scores_gemma":[0.991999,0.000935856,0.003253237,0.001158155,0.001526363,0.00001479867,0.0002106721,0.00003888985,0.0008629817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3777496,"threshold_uncertainty_score":0.7420566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01886275332194613,"score_gpt":0.3443496147018268,"score_spread":0.3254868613798806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}