{"id":"W3128167085","doi":"10.2147/ijn.s290466","title":"Preparation, Characterization, Pharmacokinetic, and Therapeutic Potential of Novel 6-Mercaptopurine-Loaded Oral Nanomedicines for Acute Lymphoblastic Leukemia","year":2021,"lang":"en","type":"article","venue":"International Journal of Nanomedicine","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Science and Technology Major Project; Beijing Children's Hospital, Capital Medical University; Children's Health Research Institute","keywords":"Pharmacology; Pharmacokinetics; Bioavailability; In vivo; Jurkat cells; In vitro; Medicine; Materials science; Chemistry; Immunology; Biology; Biochemistry; Immune system; T cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001492744,0.0002473595,0.0001185694,0.0001451067,0.0001002645,0.0001272968,0.0001242579,0.000200543,0.0004093409],"category_scores_gemma":[0.0001792685,0.00008017129,0.0001246298,0.00009285106,0.0001208405,0.0002194707,0.00009378738,0.0001855859,0.0001385183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001878467,"about_ca_system_score_gemma":0.0001079793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002023857,"about_ca_topic_score_gemma":0.0002792477,"domain_scores_codex":[0.9999298,0.00001363726,0.000005442943,0.00001634354,0.00002664251,0.000008017181],"domain_scores_gemma":[0.9999294,0.00001485083,0.00003092011,0.000004206463,0.00001377377,0.000006768386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006261397,0.00002301726,0.0001733757,0.00008103908,0.000003968938,0.00004216527,0.00001593142,0.0003126837,0.9940743,0.00006241412,0.00003947172,0.005109165],"study_design_scores_gemma":[0.00001343059,0.0005483711,0.001224628,0.000005380272,0.00001525727,0.0002563723,0.000008512709,0.002215007,0.9920684,0.00002579702,0.003612046,0.000006839247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820578,0.004806868,0.01169119,0.00009532309,0.00002421365,0.00007771754,0.0001072243,0.00005677521,0.001082831],"genre_scores_gemma":[0.9831819,0.002329316,0.01298893,0.00005044463,0.00001362533,0.00008736172,0.000150162,0.00002280656,0.001175517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004093409,"threshold_uncertainty_score":0.001369357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01886275332194613,"score_gpt":0.3443496147018268,"score_spread":0.3254868613798806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}