{"id":"W3128198726","doi":"10.1002/alz.12302","title":"Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Caprion (Canada)","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging","keywords":"Tolerability; Biomarker; Ex vivo; In vivo; Alzheimer's disease; Medicine; Pharmacology; Genetically modified mouse; Receptor; Pathology; Oncology; Internal medicine; Transgene; Chemistry; Disease; Biology; Biochemistry; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005169212,0.0001721925,0.0002687129,0.00002452273,0.00006508951,0.00001602177,0.0001498225,0.0001276428,0.00002149953],"category_scores_gemma":[0.0003180355,0.0001496708,0.0001542917,0.00010624,0.000135309,0.000006372047,0.0003638478,0.00008157019,0.000007690444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001362695,"about_ca_system_score_gemma":0.00007035014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003098962,"about_ca_topic_score_gemma":0.000001962954,"domain_scores_codex":[0.9984106,0.000163291,0.0004428489,0.0006017659,0.0001556188,0.0002258703],"domain_scores_gemma":[0.9990155,0.00008050422,0.0001158826,0.0003228584,0.0001783708,0.0002868596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008454912,0.002704644,0.007535677,0.00003371609,0.03513063,0.000007640729,0.00007027759,0.00005305688,0.8471567,0.001164937,0.009060415,0.09623683],"study_design_scores_gemma":[0.00372668,0.001141725,0.1375887,0.00005505603,0.03220647,0.00001339009,0.0002098693,0.002055886,0.786585,0.0004907158,0.0349387,0.0009878074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7491291,0.2401498,0.008133407,0.0005328324,0.0007073401,0.0007660384,0.00006654695,0.00002619689,0.0004887523],"genre_scores_gemma":[0.987746,0.001146998,0.0100562,0.0006986259,0.0001298734,0.0000741731,0.0001234417,0.00001720852,0.000007486953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2390027,"threshold_uncertainty_score":0.6103399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1582871649049838,"score_gpt":0.4133029228342438,"score_spread":0.25501575792926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}