{"id":"W3128198726","doi":"10.1002/alz.12302","title":"Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Caprion (Canada)","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging","keywords":"Tolerability; Biomarker; Ex vivo; In vivo; Alzheimer's disease; Medicine; Pharmacology; Genetically modified mouse; Receptor; Pathology; Oncology; Internal medicine; Transgene; Chemistry; Disease; Biology; Biochemistry; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007556429,0.001094263,0.001004973,0.0005904084,0.0002444996,0.0006995645,0.0007420208,0.00109169,0.003743201],"category_scores_gemma":[0.0003501369,0.0002293199,0.0006606722,0.0004740962,0.0005498611,0.0005261048,0.000241357,0.001379363,0.0006371958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004624063,"about_ca_system_score_gemma":0.0008183636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000670392,"about_ca_topic_score_gemma":0.001722097,"domain_scores_codex":[0.9997887,0.00005996326,0.00002323114,0.00004459887,0.00004217711,0.00004134382],"domain_scores_gemma":[0.9997123,0.0000224392,0.00007687591,0.00002481129,0.00004975463,0.0001139175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1202191,0.03098506,0.003280058,0.002524717,0.0007647994,0.0007987866,0.0002542106,0.001524253,0.6304318,0.001369381,0.005222843,0.202625],"study_design_scores_gemma":[0.1106161,0.6339141,0.01785959,0.0003498744,0.001552677,0.001884049,0.0001465065,0.001647361,0.1933058,0.0006735361,0.03794016,0.0001102829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735891,0.01648901,0.002231376,0.0007391757,0.0002858351,0.002306829,0.001372475,0.0001582109,0.00282801],"genre_scores_gemma":[0.9746054,0.01137212,0.00390181,0.0005372053,0.0001897351,0.001829525,0.001349701,0.00003330677,0.00618127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003743201,"threshold_uncertainty_score":0.01252228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1582871649049838,"score_gpt":0.4133029228342438,"score_spread":0.25501575792926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}