{"id":"W3128258333","doi":"10.1016/j.semcdb.2020.11.010","title":"Animal models of Fanconi anemia: A developmental and therapeutic perspective on a multifaceted disease","year":2021,"lang":"en","type":"review","venue":"Seminars in Cell and Developmental Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Biology; Fanconi anemia; Zebrafish; Bone marrow failure; Disease; Pathogenesis; Haematopoiesis; Bioinformatics; Cancer research; Immunology; Genetics; Gene; Pathology; DNA repair; Stem cell; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001731935,0.0004945388,0.0009446198,0.0001590291,0.00005920601,0.00001237316,0.0001742707,0.0005207334,0.00001967873],"category_scores_gemma":[0.00004557057,0.0004346752,0.0001338547,0.0001495822,0.000223991,0.000003863973,0.000432871,0.000245057,0.000003549802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001688877,"about_ca_system_score_gemma":0.0006922397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001625151,"about_ca_topic_score_gemma":0.0000139098,"domain_scores_codex":[0.9979598,0.00018536,0.0004768481,0.0009400457,0.00009191883,0.000346031],"domain_scores_gemma":[0.9993953,0.00007357572,0.0001778551,0.0001639011,0.00004809262,0.0001413399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000707729,0.000898163,0.0009515245,0.006916684,0.000650353,0.0002805349,0.002359126,0.000003100766,0.07646098,0.001693608,0.0002242835,0.9088539],"study_design_scores_gemma":[0.01025649,0.006289164,0.0004224383,0.03253271,0.001560115,0.00223717,0.02934531,0.0001928074,0.1531025,0.0035255,0.7510675,0.009468239],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06643167,0.9317627,0.00001338046,0.000007918916,0.00007504323,0.0005254943,0.0001140299,0.000009544329,0.001060228],"genre_scores_gemma":[0.03935315,0.9562522,0.003449687,0.00008371355,0.00002370567,0.000111025,0.0003865274,0.00004463748,0.0002953893],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8993857,"threshold_uncertainty_score":0.9998105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02243907202230734,"score_gpt":0.2924024220687493,"score_spread":0.269963350046442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}