{"id":"W3128296432","doi":"10.1016/j.coche.2021.100673","title":"Nanotechnology-mediated therapeutic strategies against synucleinopathies in neurodegenerative disease","year":2021,"lang":"en","type":"article","venue":"Current Opinion in Chemical Engineering","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institutes of Health","keywords":"Synucleinopathies; Disease; Nanocarriers; Neuroscience; Medicine; Therapeutic approach; Mechanism (biology); Bioinformatics; Parkinson's disease; Biology; Pharmacology; Drug; Alpha-synuclein; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003919088,0.0001980771,0.0002615124,0.0001597973,0.00001429574,0.00002070586,0.00006482033,0.00008622713,0.00001448093],"category_scores_gemma":[0.0001424755,0.0001925272,0.00006839877,0.0004028046,0.00002746526,0.00008368192,0.00005470348,0.0003257697,0.00000986538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001247109,"about_ca_system_score_gemma":0.0001505855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001256801,"about_ca_topic_score_gemma":2.659154e-7,"domain_scores_codex":[0.9989493,0.00001794812,0.0002404477,0.0003559359,0.0001578412,0.0002784619],"domain_scores_gemma":[0.999537,0.00004577414,0.00002821384,0.0002012065,0.00003521142,0.0001526031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003745766,0.003429527,0.02804134,0.002582596,0.0001687495,0.0009067471,0.0005506835,0.00890921,0.9098179,0.01003795,0.0001090582,0.03507163],"study_design_scores_gemma":[0.01991955,0.0002707829,0.158671,0.009482792,0.0002130376,0.00008982019,0.0007735651,0.3035998,0.4694327,0.002644102,0.03248714,0.002415787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855056,0.0124204,0.0004674407,0.0003594095,0.0008597586,0.0002013905,0.00002674373,0.0001375607,0.00002165942],"genre_scores_gemma":[0.9981018,0.001206886,0.0002494674,0.00002959949,0.00008255594,0.00008831531,0.0002139689,0.00002481026,0.000002559123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4403853,"threshold_uncertainty_score":0.7851031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02839325673494624,"score_gpt":0.2870957239464608,"score_spread":0.2587024672115145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}