{"id":"W3128314035","doi":"10.14814/phy2.14721","title":"Lower plasma PCSK9 in normocholesterolemic subjects is associated with upregulated adipose tissue surface‐expression of LDLR and CD36 and NLRP3 inflammasome","year":2021,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Heart Institute; Université de Montréal; Montreal Clinical Research Institute","funders":"Institute of Nutrition, Metabolism and Diabetes; Canadian Institutes of Health Research","keywords":"Inflammasome; PCSK9; CD36; Downregulation and upregulation; Adipose tissue; LDL receptor; Medicine; Expression (computer science); Pathology; Inflammation; Internal medicine; Biology; Receptor; Cholesterol; Computer science; Lipoprotein; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001606152,0.0002850431,0.0004627163,0.0004499307,0.0004525744,0.0003744774,0.0001149894,0.0002728421,0.002895725],"category_scores_gemma":[0.0003085739,0.0001877056,0.0002617043,0.000427724,0.0002518097,0.0001403948,0.0002292817,0.0004017772,0.0002748752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001399282,"about_ca_system_score_gemma":0.0001738979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002001906,"about_ca_topic_score_gemma":0.001621646,"domain_scores_codex":[0.9998349,0.00002129465,0.00002083062,0.00006656969,0.00002436557,0.00003205795],"domain_scores_gemma":[0.9997129,0.0000471149,0.0001039168,0.00002526272,0.00002237926,0.00008833664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007377776,0.0003123715,0.9465456,0.00006806732,0.000233911,0.0005642503,0.0002105646,0.00008324008,0.03861289,0.000093931,0.0001646881,0.005732671],"study_design_scores_gemma":[0.00003389078,0.0004053054,0.9976888,0.000002218691,0.00005922332,0.0005489265,0.0000705987,0.0001042417,0.0009270039,0.00004665791,0.0001103097,0.000002937551],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999431,0.0001067003,0.0001229089,0.00001483942,0.00000416929,0.000004916673,0.0001150913,0.000005415417,0.0001948821],"genre_scores_gemma":[0.9994649,0.0000275444,0.0001150651,0.00001169681,0.000006222028,0.000006601433,0.0001348217,0.000002093353,0.0002311699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002895725,"threshold_uncertainty_score":0.009687126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01339243444201884,"score_gpt":0.2464679233473679,"score_spread":0.233075488905349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}