{"id":"W3128314035","doi":"10.14814/phy2.14721","title":"Lower plasma PCSK9 in normocholesterolemic subjects is associated with upregulated adipose tissue surface‐expression of LDLR and CD36 and NLRP3 inflammasome","year":2021,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Heart Institute; Université de Montréal; Montreal Clinical Research Institute","funders":"Institute of Nutrition, Metabolism and Diabetes; Canadian Institutes of Health Research","keywords":"Inflammasome; PCSK9; CD36; Downregulation and upregulation; Adipose tissue; LDL receptor; Medicine; Expression (computer science); Pathology; Inflammation; Internal medicine; Biology; Receptor; Cholesterol; Computer science; Lipoprotein; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003614754,0.0002000432,0.0007368247,0.00003901549,0.00004384035,0.00001300676,0.00002847513,0.0002308586,0.00004896399],"category_scores_gemma":[0.0003205548,0.000133778,0.00007479278,0.0002542209,0.0001220252,0.00007644919,0.0001061308,0.000262678,8.873488e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004226057,"about_ca_system_score_gemma":0.0001113767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008131578,"about_ca_topic_score_gemma":0.0000233774,"domain_scores_codex":[0.9982182,0.000128339,0.0004600873,0.0005325367,0.0003704067,0.000290406],"domain_scores_gemma":[0.9989257,0.00006045622,0.0002273168,0.0004308684,0.0001623325,0.0001933334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003796332,0.0003200601,0.05942304,0.0002116069,0.0001278259,0.004302912,0.0002247853,0.00005860997,0.9318504,0.000004004159,0.00005200598,0.003045134],"study_design_scores_gemma":[0.001495884,0.0006107416,0.7626473,0.0007117821,0.00007582128,0.0006792327,0.0000314436,0.00005088086,0.233257,0.0001545264,0.0001284533,0.0001570048],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979408,0.00126276,0.000003968848,0.0001137443,0.00004253158,0.0004141912,0.000004548544,0.00003532595,0.0001821551],"genre_scores_gemma":[0.9991683,0.00023701,0.0001954546,0.0001457657,0.00002908088,0.00001196416,0.00004961989,0.00001787888,0.0001449044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7032242,"threshold_uncertainty_score":0.5455309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01339243444201884,"score_gpt":0.2464679233473679,"score_spread":0.233075488905349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}