{"id":"W3128316783","doi":"10.3389/fgene.2020.629373","title":"Recent Consanguinity and Outbred Autozygosity Are Associated With Increased Risk of Late-Onset Alzheimer’s Disease","year":2021,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Engineering and Physical Sciences Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; IXICO; Servier; Eisai; Northern California Institute for Research and Education; Illinois Department of Public Health; Rush University; Genentech; National Alzheimer's Coordinating Center; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; European Federation of Pharmaceutical Industries and Associations; Translational Genomics Research Institute; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; H. Lundbeck A/S; McKnight Foundation; Alzheimer's Association; Foundation for the National Institutes of Health; European Commission; Alzheimer's Disease Neuroimaging Initiative; Medical Research Council; Meso Scale Diagnostics","keywords":"Consanguinity; Inbreeding; Runs of Homozygosity; Demography; Population; Ethnic group; Genome-wide association study; Medicine; Biology; Genetics; Pediatrics; Genotype; Single-nucleotide polymorphism; Political science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002866202,0.0009801567,0.001658049,0.001409292,0.0005925275,0.001336212,0.0007109196,0.0008923588,0.001705159],"category_scores_gemma":[0.005757462,0.000616563,0.005471809,0.002175901,0.0005051948,0.0005616597,0.0006716119,0.001020241,0.0001202339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002409386,"about_ca_system_score_gemma":0.0003345856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005891879,"about_ca_topic_score_gemma":0.01019074,"domain_scores_codex":[0.9979931,0.0009757716,0.0002223987,0.0005246475,0.0001588116,0.0001252494],"domain_scores_gemma":[0.9962864,0.002249879,0.0006709254,0.0004259304,0.0001821325,0.0001847145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00781661,0.00009711437,0.7949024,0.002888877,0.1620287,0.001005063,0.0002491768,0.0009355632,0.003260938,0.0004401574,0.0006480793,0.02572729],"study_design_scores_gemma":[0.0004699531,0.00067566,0.8382045,0.0007082123,0.1512345,0.00121262,0.0001940427,0.002747694,0.0007038522,0.001164238,0.002645239,0.00003957019],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8487895,0.1462942,0.002194213,0.0005064473,0.000194516,0.00002704787,0.0006487931,0.00006214331,0.001283238],"genre_scores_gemma":[0.9871194,0.01159109,0.0005459636,0.0001347254,0.00009751743,0.0000122129,0.0002831978,0.00001489012,0.0002010325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005891879,"threshold_uncertainty_score":0.01515812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192621069327889,"score_gpt":0.2287044564707841,"score_spread":0.2167782457775052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}