{"id":"W3128316783","doi":"10.3389/fgene.2020.629373","title":"Recent Consanguinity and Outbred Autozygosity Are Associated With Increased Risk of Late-Onset Alzheimer’s Disease","year":2021,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Engineering and Physical Sciences Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; IXICO; Servier; Eisai; Northern California Institute for Research and Education; Illinois Department of Public Health; Rush University; Genentech; National Alzheimer's Coordinating Center; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; European Federation of Pharmaceutical Industries and Associations; Translational Genomics Research Institute; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; H. Lundbeck A/S; McKnight Foundation; Alzheimer's Association; Foundation for the National Institutes of Health; European Commission; Alzheimer's Disease Neuroimaging Initiative; Medical Research Council; Meso Scale Diagnostics","keywords":"Consanguinity; Inbreeding; Runs of Homozygosity; Demography; Population; Ethnic group; Genome-wide association study; Medicine; Biology; Genetics; Pediatrics; Genotype; Single-nucleotide polymorphism; Political science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001973278,0.000162111,0.000421582,0.00008133709,0.00006266246,0.000009798886,0.00005267287,0.0001687607,0.00003020195],"category_scores_gemma":[0.0006251194,0.0001403659,0.00005345263,0.0003388326,0.0002317059,0.00001674181,0.00004958445,0.000284728,8.305025e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000056119,"about_ca_system_score_gemma":0.0003578977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005380507,"about_ca_topic_score_gemma":0.00009271305,"domain_scores_codex":[0.9987647,0.0002075231,0.0002843869,0.000271325,0.0002316861,0.0002403973],"domain_scores_gemma":[0.9989798,0.00004891335,0.0001853254,0.0002988252,0.0002158984,0.0002712581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003698046,0.0003717984,0.9888451,0.00003855149,0.0004208656,0.0002555176,0.0002512916,0.0001216392,0.00002190703,7.538947e-7,0.00436456,0.004938251],"study_design_scores_gemma":[0.003449789,0.0001270249,0.9883549,0.0002576414,0.001115543,0.000008224279,0.000943353,0.003338116,0.000648992,0.0001454187,0.001433488,0.0001774935],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658481,0.03259324,0.0001100974,0.0004352156,0.0002013449,0.0002977831,0.0002435556,0.00002888633,0.0002417841],"genre_scores_gemma":[0.9811844,0.01530594,0.002979285,0.0002724019,0.00001151695,0.000006172897,0.0001523874,0.00002296114,0.00006492679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0172873,"threshold_uncertainty_score":0.5723956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192621069327889,"score_gpt":0.2287044564707841,"score_spread":0.2167782457775052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}