{"id":"W3128359329","doi":"10.1038/s41588-020-00770-2","title":"Metabolic control of DNA methylation in naive pluripotent cells","year":2021,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; Biotechnology and Biological Sciences Research Council; Ministero dell’Istruzione, dell’Università e della Ricerca; Medical Research Council; Giovanni Armenise-Harvard Foundation; Associazione Italiana per la Ricerca sul Cancro; European Foundation for the Study of Diabetes; Università degli Studi di Milano; Eli Lilly and Company","keywords":"Biology; DNA methylation; DNMT3B; Epigenetics; Methylation; Epigenome; Cell biology; Epiblast; Molecular biology; Embryonic stem cell; Genetics; Gene expression; Gene; Gastrulation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002356051,0.0001419532,0.000215611,0.00006957909,0.00002392333,0.00001148097,0.0001218282,0.0004513082,0.00001675474],"category_scores_gemma":[0.0001216848,0.000146655,0.0001054186,0.0002119768,0.00003609452,0.000001965979,0.0000579906,0.0002033097,0.000002679939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001012383,"about_ca_system_score_gemma":0.0001195072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000396273,"about_ca_topic_score_gemma":0.00004617652,"domain_scores_codex":[0.9988368,0.0001284013,0.0003177033,0.0003197781,0.0002062346,0.0001911319],"domain_scores_gemma":[0.9991439,0.00002303377,0.0001289019,0.0003543814,0.0002927925,0.0000569709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002813135,0.0000651005,0.00514671,0.0000145893,0.00004271607,0.000003819748,0.00004403656,0.002579985,0.9858776,0.00009744892,0.00003931711,0.006060575],"study_design_scores_gemma":[0.0007843089,0.00007554837,0.02553449,0.000008103927,0.0000375259,0.000001209302,0.00002682323,0.000323074,0.9483774,0.0004199937,0.02426974,0.0001418159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9278882,0.06538326,0.005508803,0.00009246915,0.0003602466,0.0001633174,0.00004056584,0.000004097103,0.0005590944],"genre_scores_gemma":[0.9925108,0.003831908,0.003011798,0.00016493,0.0001853179,0.00000743903,0.0001115143,0.00002070774,0.0001555893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06462265,"threshold_uncertainty_score":0.5980417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005880120046647593,"score_gpt":0.2489337508652406,"score_spread":0.243053630818593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}