{"id":"W3128359329","doi":"10.1038/s41588-020-00770-2","title":"Metabolic control of DNA methylation in naive pluripotent cells","year":2021,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; Biotechnology and Biological Sciences Research Council; Ministero dell’Istruzione, dell’Università e della Ricerca; Medical Research Council; Giovanni Armenise-Harvard Foundation; Associazione Italiana per la Ricerca sul Cancro; European Foundation for the Study of Diabetes; Università degli Studi di Milano; Eli Lilly and Company","keywords":"Biology; DNA methylation; DNMT3B; Epigenetics; Methylation; Epigenome; Cell biology; Epiblast; Molecular biology; Embryonic stem cell; Genetics; Gene expression; Gene; Gastrulation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001974313,0.0001640682,0.0002104105,0.0002091481,0.0002077773,0.0006676443,0.0002965217,0.0003003282,0.0009969173],"category_scores_gemma":[0.000261207,0.0001606935,0.0001863236,0.0001794631,0.0002325939,0.0003689519,0.0003069112,0.0005731903,0.0002767436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004665197,"about_ca_system_score_gemma":0.0002045469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006470815,"about_ca_topic_score_gemma":0.001403154,"domain_scores_codex":[0.9998327,0.00003615246,0.00001356308,0.00004370474,0.00004957012,0.00002419115],"domain_scores_gemma":[0.9998469,0.00003115987,0.00003018862,0.0000261341,0.00002788865,0.00003771999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001343517,0.000005890079,0.0004421828,0.0000231247,0.000004605648,0.00004375042,0.00001848798,0.0001393519,0.9948016,0.001524823,0.00004851429,0.002813277],"study_design_scores_gemma":[0.00001271952,0.00009743807,0.009362003,0.000006028162,0.000009061839,0.0001503816,0.00004493902,0.001609845,0.9851232,0.001402823,0.002170253,0.00001140091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688599,0.004084677,0.01957996,0.0006036257,0.0001215049,0.00002040874,0.001130504,0.000187218,0.005412234],"genre_scores_gemma":[0.9918549,0.000838446,0.003351156,0.00007478049,0.00001827932,0.00001144992,0.0005741304,0.0000325664,0.003244213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009969173,"threshold_uncertainty_score":0.003384888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005880120046647593,"score_gpt":0.2489337508652406,"score_spread":0.243053630818593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}