{"id":"W3128385432","doi":"10.1007/s11095-021-02990-5","title":"Pharmacokinetic and Tissue Distribution of Orally Administered Cyclosporine A-Loaded poly(ethylene oxide)-block-Poly(ε-caprolactone) Micelles versus Sandimmune® in Rats","year":2021,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Deanship of Scientific Research, King Saud University","keywords":"Pharmacokinetics; Micelle; Chemistry; Biodistribution; Pharmacology; Distribution (mathematics); Ethylene oxide; Dosage form; In vivo; Bioavailability; Oral administration; Caprolactone; Chromatography; In vitro; Medicine; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002973922,0.0005069614,0.0008590802,0.0003616026,0.0003210218,0.00005649931,0.0005928962,0.0005261762,0.001242079],"category_scores_gemma":[0.00117293,0.0005343638,0.0001356408,0.001510356,0.001052498,0.0002751212,0.000740346,0.002900229,0.0001951531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003603669,"about_ca_system_score_gemma":0.000480729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001194298,"about_ca_topic_score_gemma":0.00005281797,"domain_scores_codex":[0.9921956,0.002900748,0.001218913,0.001039495,0.001027867,0.00161738],"domain_scores_gemma":[0.9942579,0.003400137,0.0002098709,0.0005304748,0.000715071,0.0008865339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009343924,0.001215933,0.00514891,0.0005205773,0.0002846617,0.0009313418,0.0004656785,0.00009673559,0.9286503,0.0006734452,0.0007800992,0.05188845],"study_design_scores_gemma":[0.009344107,0.0003249386,0.003290919,0.0001059734,0.0001456207,0.00008795723,0.0004798744,0.003115062,0.8389435,0.0001471404,0.1435577,0.0004572827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9548877,0.03800057,0.0001311697,0.002396055,0.001116409,0.001160543,0.0003005872,0.00008838344,0.001918536],"genre_scores_gemma":[0.9928541,0.004664252,0.0002552792,0.000221383,0.0002677409,0.0001485012,0.0002173502,0.00006941632,0.001302047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1427776,"threshold_uncertainty_score":0.9997108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2793465893966643,"score_gpt":0.5332680578453187,"score_spread":0.2539214684486544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}