{"id":"W3128385432","doi":"10.1007/s11095-021-02990-5","title":"Pharmacokinetic and Tissue Distribution of Orally Administered Cyclosporine A-Loaded poly(ethylene oxide)-block-Poly(ε-caprolactone) Micelles versus Sandimmune® in Rats","year":2021,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Deanship of Scientific Research, King Saud University","keywords":"Pharmacokinetics; Micelle; Chemistry; Biodistribution; Pharmacology; Distribution (mathematics); Ethylene oxide; Dosage form; In vivo; Bioavailability; Oral administration; Caprolactone; Chromatography; In vitro; Medicine; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002688322,0.0005710038,0.0004985404,0.0004091981,0.0002082801,0.0003486658,0.0003209212,0.0004954648,0.001233634],"category_scores_gemma":[0.0002885819,0.000310406,0.0003603885,0.0002907762,0.0004622985,0.0006006646,0.00009158845,0.001093617,0.0004981694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004774946,"about_ca_system_score_gemma":0.0008182571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002280997,"about_ca_topic_score_gemma":0.002560504,"domain_scores_codex":[0.999832,0.00002426796,0.00001065002,0.00004737726,0.00002962318,0.00005605137],"domain_scores_gemma":[0.9997309,0.00006392689,0.00007541126,0.00002637895,0.00002834886,0.00007495238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02402364,0.001918387,0.0006708303,0.0001391627,0.00006211542,0.0001343748,0.0001122566,0.001851661,0.9574031,0.0003087379,0.0003390304,0.01303668],"study_design_scores_gemma":[0.0006254314,0.02796835,0.004712641,0.00001273018,0.0001976193,0.0001712007,0.00007972625,0.004602426,0.9596284,0.0001545037,0.001805127,0.00004190299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952925,0.001117317,0.001649793,0.0001052769,0.00009105833,0.00005380106,0.0004412485,0.0001262006,0.001122879],"genre_scores_gemma":[0.9892886,0.001573074,0.001596207,0.00006736961,0.00005337824,0.00008968265,0.0004613892,0.00004242052,0.006827887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002280997,"threshold_uncertainty_score":0.004535437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2793465893966643,"score_gpt":0.5332680578453187,"score_spread":0.2539214684486544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}