{"id":"W3128441290","doi":"10.1016/j.cmet.2020.10.024","title":"Low-Calorie Sweeteners with Carbohydrate Do Not Impair Insulin Sensitivity in Humans: Re-analysis Highlighting the Importance of the Comparator","year":2021,"lang":"en","type":"letter","venue":"Cell Metabolism","topic":"Biochemical Analysis and Sensing Techniques","field":"Nursing","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Obesity Canada; International Sweeteners Association; European Association for the Study of Diabetes; Ontario Ministry of Research, Innovation and Science; Physicians' Services Incorporated Foundation; Canada Foundation for Innovation; International Life Sciences Institute; International Nut and Dried Fruit Council; Glycemic Index Foundation; Diabetes Canada; Canadian Cardiovascular Society; Canadian Institutes of Health Research; Almond Board of California; Dairy Farmers of Canada; California Health Care Safety Net Institute; Physicians Committee for Responsible Medicine; Ontario Ministry of Research and Innovation; Ontario Research Foundation; Abbott Fund; National Dried Fruit Trade Association; European Food Safety Authority","keywords":"Sucralose; Sugar; Carbohydrate; Sucrose; Food science; Maltodextrin; Carbohydrate metabolism; Calorie; Insulin sensitivity; Chemistry; Insulin; Endocrinology; Biochemistry; Medicine; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001135566,0.0006726907,0.002040993,0.0003224644,0.000234571,0.0001543736,0.0006601569,0.0007652334,0.00002705253],"category_scores_gemma":[0.0001152618,0.0003689901,0.001111694,0.002791521,0.0004754645,0.00007547462,0.0002343532,0.002520019,0.000002545279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001234868,"about_ca_system_score_gemma":0.0000860171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009592146,"about_ca_topic_score_gemma":0.001268464,"domain_scores_codex":[0.9950879,0.001192124,0.001122994,0.00103085,0.0009196454,0.0006464559],"domain_scores_gemma":[0.9958906,0.0004486653,0.001206753,0.002005177,0.000381492,0.00006736038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000498887,0.0007027491,0.02520385,0.001130309,0.006495406,0.00126586,0.004969795,0.001530811,0.5753602,0.0002928466,0.3820737,0.00047556],"study_design_scores_gemma":[0.0008236652,0.0000404663,0.01413781,0.0005719775,0.01233615,0.000005626614,0.0003244621,0.001864442,0.9052956,0.0004966392,0.06252261,0.001580573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8510047,0.002675847,0.00008784714,0.1445847,0.0005236555,0.0004539537,0.00008072091,0.0001033496,0.0004851984],"genre_scores_gemma":[0.903064,0.00006353149,0.0007190226,0.09474553,0.001036094,0.00001829305,0.0001436987,0.00007861404,0.0001312734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3299353,"threshold_uncertainty_score":0.9998762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577138552618528,"score_gpt":0.2315827678251223,"score_spread":0.215811382298937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}