{"id":"W3128446235","doi":"10.1136/gutjnl-2020-323636","title":"Autoimmune susceptibility gene <i>PTPN2</i> is required for clearance of adherent-invasive <i>Escherichia coli</i> by integrating bacterial uptake and lysosomal defence","year":2021,"lang":"en","type":"article","venue":"Gut","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Occupational Cancer Research Centre","funders":"National Institute of Allergy and Infectious Diseases; Hartmann Müller-Stiftung für Medizinische Forschung; Crohn's and Colitis Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; McGill University; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; National Science Foundation","keywords":"Biology; Microbiology; Immune system; Immunology; Macrophage; Inflammation; Escherichia coli; Inflammatory bowel disease; Gene; In vitro; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001533061,0.0001910883,0.0002695099,0.000008757421,0.00008535603,0.00003268266,0.0001780325,0.000145047,0.0000347909],"category_scores_gemma":[0.000544835,0.0001971851,0.00009689689,0.0001025211,0.000157703,0.00001116712,0.0001786661,0.00007169755,0.000002148031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001374769,"about_ca_system_score_gemma":0.0002229845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005793112,"about_ca_topic_score_gemma":0.00008710292,"domain_scores_codex":[0.9986867,0.00006381418,0.0003645526,0.0005088456,0.0001072197,0.000268865],"domain_scores_gemma":[0.9990052,0.00003352196,0.0001847265,0.0004488329,0.0002594349,0.00006825927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003463622,0.00006557087,0.0006786725,0.0000954312,0.00004534655,0.000001625863,0.00004681422,9.235046e-7,0.9930258,0.00008277508,0.003493578,0.002117126],"study_design_scores_gemma":[0.001027655,0.0003252304,0.002352121,0.00005037782,0.00002887443,0.000006254138,0.00007264951,0.000021043,0.9853479,0.0000801326,0.01049133,0.0001964364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852272,0.01141169,0.001479599,0.0001334703,0.0001765052,0.000389483,0.001115839,0.00001385558,0.00005233532],"genre_scores_gemma":[0.9869891,0.000381828,0.01104848,0.0003624941,0.0001201394,0.00007411568,0.0007937412,0.00002704375,0.0002030974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01102986,"threshold_uncertainty_score":0.8040974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01191866490054564,"score_gpt":0.2435021679764226,"score_spread":0.231583503075877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}