{"id":"W3128446235","doi":"10.1136/gutjnl-2020-323636","title":"Autoimmune susceptibility gene <i>PTPN2</i> is required for clearance of adherent-invasive <i>Escherichia coli</i> by integrating bacterial uptake and lysosomal defence","year":2021,"lang":"en","type":"article","venue":"Gut","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Occupational Cancer Research Centre","funders":"National Institute of Allergy and Infectious Diseases; Hartmann Müller-Stiftung für Medizinische Forschung; Crohn's and Colitis Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; McGill University; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; National Science Foundation","keywords":"Biology; Microbiology; Immune system; Immunology; Macrophage; Inflammation; Escherichia coli; Inflammatory bowel disease; Gene; In vitro; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001360554,0.0003812696,0.0002696362,0.0001771803,0.0001561822,0.0003381119,0.0002029473,0.0004054588,0.002093037],"category_scores_gemma":[0.0001830905,0.0001657909,0.0002781317,0.0001133292,0.0003361726,0.0001515963,0.0002264657,0.0005498569,0.0004798867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002381833,"about_ca_system_score_gemma":0.0001761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005512417,"about_ca_topic_score_gemma":0.0006183744,"domain_scores_codex":[0.9997893,0.00003776568,0.00002391651,0.00006136164,0.00004108334,0.00004652733],"domain_scores_gemma":[0.9997165,0.00002960569,0.0001367926,0.00002012596,0.00002023352,0.00007667832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000209507,0.00001585355,0.0008031071,0.00002774775,0.000006616538,0.0002006905,0.0000108565,0.00003842882,0.9980825,0.0000563473,0.00004204286,0.0005063383],"study_design_scores_gemma":[0.0001323223,0.0007392992,0.0876132,0.00003876234,0.00009887583,0.006390864,0.0001818939,0.002746152,0.8965068,0.0001499981,0.005382958,0.00001897386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959095,0.0007363881,0.002103994,0.00009211673,0.0000275007,0.00001670477,0.0003678665,0.00006797881,0.000677845],"genre_scores_gemma":[0.9973361,0.000279761,0.000961335,0.00004681562,0.00001218799,0.00002288093,0.0004134213,0.00001994299,0.0009075384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002093037,"threshold_uncertainty_score":0.007001936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01191866490054564,"score_gpt":0.2435021679764226,"score_spread":0.231583503075877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}