{"id":"W3128464463","doi":"10.1101/2021.02.08.430060","title":"CIP2A is a prime synthetic-lethal target for BRCA-mutated cancers","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Aegera Therapeutics (Canada); Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Associazione Italiana per la Ricerca sul Cancro; Krembil Foundation","keywords":"Homologous recombination; Biology; Genome instability; Mitosis; Genetics; Synthetic lethality; DNA repair; Cas9; CRISPR; Cancer research; DNA; Gene; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001445136,0.0004804953,0.0002999119,0.0004295924,0.0004347772,0.0004574596,0.0001914724,0.0003804595,0.003456314],"category_scores_gemma":[0.0001358473,0.0002344803,0.0001921855,0.0002640525,0.0002373749,0.000172295,0.0003917147,0.0008078153,0.001968297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003945222,"about_ca_system_score_gemma":0.0003424875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007115547,"about_ca_topic_score_gemma":0.0009262903,"domain_scores_codex":[0.999861,0.000008906029,0.000004832846,0.00002717586,0.00007918947,0.00001884641],"domain_scores_gemma":[0.9999461,0.000007223874,0.00001203627,0.00001011167,0.000008132988,0.0000164384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008016668,0.00001350339,0.0002646362,0.000078323,0.000008429217,0.0001382928,0.0000107641,0.0002501751,0.9920635,0.0008037008,0.001300692,0.004987836],"study_design_scores_gemma":[0.00001596228,0.00006110382,0.003086983,0.000007983494,0.00001042174,0.001190382,0.00001160872,0.001431877,0.9521796,0.0003786827,0.04161642,0.000008867712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8105691,0.02117478,0.08765366,0.003457079,0.0008031416,0.0002387968,0.007792479,0.005665622,0.06264523],"genre_scores_gemma":[0.9217588,0.005444853,0.02245836,0.0003203165,0.0001346531,0.0001317174,0.006880058,0.0005967473,0.04227455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003456314,"threshold_uncertainty_score":0.01156259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01000238536108535,"score_gpt":0.2266293550577499,"score_spread":0.2166269696966646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}