{"id":"W3128470920","doi":"10.1101/2021.02.02.429488","title":"<i>In vivo</i> antigen expression regulates CD4 T cell differentiation and vaccine efficacy against <i>Mycobacterium tuberculosis</i> infection","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; Statens Serum Institut; Lundbeckfonden; H. Lundbeck A/S; National Institutes of Health; McGill University Health Centre; McGill University","keywords":"Biology; Antigen; Mycobacterium tuberculosis; ESAT-6; Immunology; T cell; Vaccination; Immune system; Virology; Microbiology; Tuberculosis; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001340018,0.0002351479,0.0001972774,0.0001125373,0.00008059127,0.0003746733,0.0001181334,0.0002930463,0.001429895],"category_scores_gemma":[0.0001141538,0.0001072023,0.0001482394,0.0000772471,0.0001784313,0.0001657958,0.0001107354,0.0007418409,0.0005829072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002134662,"about_ca_system_score_gemma":0.00009574686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00025059,"about_ca_topic_score_gemma":0.000281157,"domain_scores_codex":[0.9998186,0.00003728994,0.00001218492,0.00003754336,0.00002661903,0.00006781],"domain_scores_gemma":[0.999858,0.00002329732,0.00005269574,0.00001088648,0.00001775909,0.00003731609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001844235,0.00003197162,0.0003120211,0.0000198747,0.000001836059,0.00001181568,0.000007586955,0.00004473588,0.9988511,0.00002004496,0.00003403777,0.0004806199],"study_design_scores_gemma":[0.00002170452,0.0008385222,0.01601659,0.00001052614,0.00001804589,0.000150964,0.00005603408,0.0009135174,0.9804941,0.00003860098,0.001437185,0.000004151334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973998,0.0006663617,0.0006540595,0.00006161977,0.00001530242,0.00001206151,0.0002379462,0.00003647256,0.0009163793],"genre_scores_gemma":[0.9976237,0.0002799367,0.0004528244,0.00005967664,0.0000124092,0.000018173,0.0003388449,0.00001914984,0.001195219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001429895,"threshold_uncertainty_score":0.004783452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01107570109374544,"score_gpt":0.246423555399639,"score_spread":0.2353478543058936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}