{"id":"W3128506218","doi":"10.1080/15592294.2021.1876297","title":"Adiposity associated DNA methylation signatures in adolescents are related to leptin and perinatal factors","year":2021,"lang":"en","type":"article","venue":"Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Erasmus+; University of Notre Dame Australia; Murdoch University; Government of Western Australia; Edith Cowan University; Raine Medical Research Foundation; National Institute for Health Research Southampton Biomedical Research Centre; European Commission; Curtin University of Technology; British Heart Foundation; Horizon 2020; Medical Research Council; University of Notre Dame; Diabetes UK; National Health and Medical Research Council; Women and Infants Research Foundation; National Institute for Health and Care Research; Australian Government","keywords":"DNA methylation; Epigenetics; Adipokine; Biology; Leptin; Methylation; Body mass index; CpG site; Endocrinology; Internal medicine; Obesity; Waist; Pregnancy; Genetics; Medicine; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002533015,0.0001784712,0.0001818056,0.00007230393,0.00007824424,0.00003870709,0.0000940725,0.0003087587,0.00002499551],"category_scores_gemma":[0.0005923568,0.0001963641,0.00005621166,0.00023534,0.00003140744,0.000003825419,0.0001428914,0.0001514404,0.000003683495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004003652,"about_ca_system_score_gemma":0.00005034211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002403113,"about_ca_topic_score_gemma":0.0006671218,"domain_scores_codex":[0.9986662,0.0002096004,0.0002762196,0.0004280624,0.0001703773,0.0002495128],"domain_scores_gemma":[0.999365,0.00002042816,0.0001022347,0.0002387996,0.0001466364,0.00012694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001579994,0.00006408279,0.3921928,0.00001599746,0.00002760681,0.000008525903,0.0001465014,0.001118278,0.6048507,0.00001307026,0.00002546022,0.00152113],"study_design_scores_gemma":[0.0002678468,0.0000775092,0.5859603,0.00003364731,0.00001133243,3.339898e-7,0.00006312377,0.00007832277,0.4125196,0.00007747672,0.0007535876,0.0001569385],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936485,0.005344829,0.0003082116,0.0001035318,0.0001660235,0.0001693472,0.00003172139,0.00001230637,0.0002154895],"genre_scores_gemma":[0.9986932,0.0003510301,0.0003057492,0.00007856544,0.00002946982,0.000005372377,0.0001299149,0.00002698368,0.0003796648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1937675,"threshold_uncertainty_score":0.8007495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009762527092359852,"score_gpt":0.2556162399600689,"score_spread":0.2458537128677091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}