{"id":"W3128528813","doi":"10.3389/fgene.2021.606537","title":"Prevalence of the Brazilian TP53 Founder c.1010G>A (p.Arg337His) in Lung Adenocarcinoma: Is Genotyping Warranted in All Brazilian Patients?","year":2021,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Azrieli Foundation; Israel Science Foundation; Hospital de Clínicas de Porto Alegre; Fundação Instituto de Pesquisas Econômicas; International Development Research Centre","keywords":"Genotyping; Adenocarcinoma; Genotype; Penetrance; Founder effect; Lung cancer; Population; Allele frequency; Allele; Germline mutation; Biology; Genetics; Germline; Cancer; Oncology; Medicine; Haplotype; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006879055,0.0003438696,0.0003823535,0.0008492757,0.000430062,0.0006467809,0.0004708565,0.0006217269,0.001146149],"category_scores_gemma":[0.003996336,0.0003509314,0.0002167643,0.0008461952,0.000610327,0.0002818204,0.0003144326,0.0003111244,0.0002894063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004186394,"about_ca_system_score_gemma":0.0003578523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01935433,"about_ca_topic_score_gemma":0.02287773,"domain_scores_codex":[0.9995604,0.00009810938,0.00005709092,0.0001062736,0.0001091141,0.00006895456],"domain_scores_gemma":[0.9988185,0.0001997413,0.0005311954,0.0001174769,0.0001938153,0.0001392828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000381845,0.00001345908,0.9930213,0.00003492607,0.00001399759,0.0007173345,0.0003353326,0.00001629412,0.001955761,0.00003085032,0.0001028257,0.003719641],"study_design_scores_gemma":[0.00001068094,0.000120651,0.9888614,0.00008301673,0.00006242833,0.007544061,0.001211568,0.0002208518,0.0004193698,0.0001224793,0.001335146,0.000008383344],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976733,0.0008716166,0.0001647076,0.0002850652,0.0000067285,0.00001215812,0.0001286135,0.000008684048,0.0008489972],"genre_scores_gemma":[0.9991422,0.0004922971,0.0001289287,0.00008308003,0.000007102861,0.00000557778,0.00008496769,0.000003125105,0.00005268081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01935433,"threshold_uncertainty_score":0.03848338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128035259771219,"score_gpt":0.2447868825826856,"score_spread":0.2335065299849734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}