{"id":"W3128528813","doi":"10.3389/fgene.2021.606537","title":"Prevalence of the Brazilian TP53 Founder c.1010G>A (p.Arg337His) in Lung Adenocarcinoma: Is Genotyping Warranted in All Brazilian Patients?","year":2021,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Azrieli Foundation; Israel Science Foundation; Hospital de Clínicas de Porto Alegre; Fundação Instituto de Pesquisas Econômicas; International Development Research Centre","keywords":"Genotyping; Adenocarcinoma; Genotype; Penetrance; Founder effect; Lung cancer; Population; Allele frequency; Allele; Germline mutation; Biology; Genetics; Germline; Cancer; Oncology; Medicine; Haplotype; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002506756,0.0002862387,0.0005104654,0.0003337209,0.00003857974,0.00001535476,0.0003614321,0.0003213452,0.0000980135],"category_scores_gemma":[0.0002158519,0.0002833834,0.0001644604,0.001070804,0.0001764841,0.00006195114,0.0002088146,0.0006518238,0.000004647206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007141556,"about_ca_system_score_gemma":0.0004570551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009280346,"about_ca_topic_score_gemma":0.0005758643,"domain_scores_codex":[0.9972499,0.0002067059,0.0007971176,0.0006240915,0.0005446231,0.0005775634],"domain_scores_gemma":[0.99857,0.00003173417,0.0001886857,0.0009216811,0.0001726246,0.0001153285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001369871,0.000317091,0.9822766,0.0006153901,0.00007230696,0.0000902445,0.003509011,0.0006427357,0.005522156,0.000009358916,0.002889047,0.003919065],"study_design_scores_gemma":[0.004405031,0.000110761,0.9641172,0.0008739575,0.0001428859,0.00001630389,0.0003729306,0.01082889,0.01686814,0.0002192541,0.001726001,0.0003186763],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682401,0.02651738,0.001536112,0.0006275876,0.001336733,0.001035125,0.00004528749,0.00001875194,0.0006428682],"genre_scores_gemma":[0.9908998,0.001524757,0.006144289,0.0008679127,0.00004872734,0.00003035381,0.00002775137,0.00006666545,0.0003897677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02499262,"threshold_uncertainty_score":0.9999619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128035259771219,"score_gpt":0.2447868825826856,"score_spread":0.2335065299849734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}