{"id":"W3128589524","doi":"10.3390/curroncol28010071","title":"Rationale and Design of BeatNF2 Trial: A Clinical Trial to Assess the Efficacy and Safety of Bevacizumab in Patients with Neurofibromatosis Type 2 Related Vestibular Schwannoma","year":2021,"lang":"en","type":"article","venue":"Current Oncology","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science","keywords":"Medicine; Bevacizumab; Neurofibromatosis type 2; Clinical trial; Placebo; Hearing loss; Surgery; Oncology; Internal medicine; Schwannoma; Chemotherapy; Audiology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02061615,0.003743329,0.004782495,0.0007995512,0.001527894,0.002336597,0.002110411,0.004794229,0.01157728],"category_scores_gemma":[0.01618294,0.00180917,0.002203865,0.0009390188,0.003061699,0.001992879,0.0008440643,0.006043348,0.004131395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001321104,"about_ca_system_score_gemma":0.005261027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005313949,"about_ca_topic_score_gemma":0.001129408,"domain_scores_codex":[0.9878421,0.008201045,0.0007231353,0.00136046,0.001088135,0.0007850708],"domain_scores_gemma":[0.9957964,0.001316847,0.0006641111,0.00039867,0.0004876787,0.001336387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9211569,0.008479694,0.003751481,0.007213627,0.002055648,0.0005387432,0.0002422691,0.00147307,0.00448532,0.006932756,0.008815445,0.03485507],"study_design_scores_gemma":[0.9251093,0.04459847,0.002749498,0.000836994,0.001138375,0.0001665697,0.00005644389,0.001387408,0.0008220228,0.003452913,0.01960463,0.00007745153],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.09073673,0.0128157,0.00943487,0.008817406,0.007033393,0.851759,0.004843757,0.0004116392,0.01414755],"genre_scores_gemma":[0.1492894,0.003727967,0.01540052,0.009758537,0.002052712,0.811847,0.001790707,0.00005916086,0.006073984],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02061615,"threshold_uncertainty_score":0.1090299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1690018503469119,"score_gpt":0.4020800782458883,"score_spread":0.2330782278989764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}