{"id":"W3128592777","doi":"10.1101/2021.01.30.428641","title":"<i>MYC</i> controls metastatic heterogeneity in pancreatic cancer","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Abramson Cancer Center; Abramson Family Cancer Research Institute; National Institutes of Health; Ontario Institute for Cancer Research; Canadian Institutes of Health Research; Cancer Research Society; University of Pennsylvania; Memorial Sloan-Kettering Cancer Center; Cancer Prevention and Research Institute of Texas; Cancer Research Institute","keywords":"Intravasation; Pancreatic cancer; Cancer research; Metastasis; Transcriptome; Cancer; Downregulation and upregulation; Pancreatic ductal adenocarcinoma; Biology; Adenocarcinoma; Medicine; Gene; Internal medicine; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002161612,0.0002078514,0.0002340653,0.000381639,0.0001602358,0.0006576549,0.0002127638,0.0002333792,0.002686267],"category_scores_gemma":[0.0002799397,0.0002163719,0.000142241,0.0002117157,0.0003003619,0.0001761193,0.0003434976,0.0004504968,0.000613222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003074812,"about_ca_system_score_gemma":0.0001519451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008032462,"about_ca_topic_score_gemma":0.0008693736,"domain_scores_codex":[0.9998307,0.00002376691,0.00001126217,0.00006530962,0.00002889971,0.00004013993],"domain_scores_gemma":[0.9996734,0.00004525414,0.0001438416,0.00003921181,0.00001629892,0.00008198374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002773379,0.00003147892,0.003746241,0.00002265204,0.000008749853,0.00006236119,0.00001378425,0.0001515173,0.9933715,0.0001709941,0.0001696675,0.001973709],"study_design_scores_gemma":[0.00009411206,0.0005384628,0.2493849,0.00002829704,0.00005952647,0.001627835,0.0002544991,0.009096457,0.7301647,0.0009772168,0.007744959,0.00002904568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934895,0.0006254721,0.002649833,0.0001463721,0.00002170571,0.00001821734,0.001145789,0.0002123417,0.001690796],"genre_scores_gemma":[0.9974499,0.000210314,0.0005798285,0.00005447631,0.00000836957,0.00001492523,0.0004662366,0.00008603565,0.001129906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002686267,"threshold_uncertainty_score":0.008986413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03654340219558047,"score_gpt":0.3150063180219014,"score_spread":0.278462915826321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}