{"id":"W3128593136","doi":"10.1186/s13063-021-05080-4","title":"Management of Renin-Angiotensin-Aldosterone System blockade in patients admitted to hospital with confirmed coronavirus disease (COVID-19) infection (The McGill RAAS-COVID- 19): A structured summary of a study protocol for a randomized controlled trial","year":2021,"lang":"en","type":"article","venue":"Trials","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; University of Alberta; Canadian VIGOUR Centre; Jewish General Hospital; McGill University; McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; National Heart, Lung, and Blood Institute; McGill University; Alberta Innovates; Amarin Pharma; European Society of Cardiology; Amarin Corporation; McGill University Health Centre","keywords":"Medicine; Discontinuation; Randomized controlled trial; Clinical endpoint; Clinical trial; Randomization; Internal medicine; Aliskiren; Coronavirus disease 2019 (COVID-19); Renin–angiotensin system; Intensive care medicine; Disease; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01981951,0.002878552,0.00534352,0.001086493,0.00149341,0.00282629,0.001771042,0.005062005,0.02127497],"category_scores_gemma":[0.02318715,0.001557505,0.004581623,0.001169031,0.001842735,0.002184991,0.001171393,0.004192068,0.003604986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002177738,"about_ca_system_score_gemma":0.006353878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008051233,"about_ca_topic_score_gemma":0.002185827,"domain_scores_codex":[0.9877073,0.008398314,0.001607727,0.0008216012,0.0007346834,0.000730379],"domain_scores_gemma":[0.9930531,0.002315237,0.002106731,0.0006012011,0.0009209178,0.001002757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9146877,0.009076603,0.001111455,0.02146726,0.002751683,0.0001528482,0.0002808803,0.001291926,0.002369878,0.002644425,0.008792074,0.03537328],"study_design_scores_gemma":[0.963983,0.02066761,0.001292324,0.002612003,0.0009866947,0.00003997052,0.00005168171,0.0008639059,0.0003633836,0.001056537,0.008032523,0.00005038936],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01285208,0.002194673,0.002551349,0.001028333,0.0007709784,0.9772714,0.001311066,0.0001148802,0.001905177],"genre_scores_gemma":[0.0143038,0.001093334,0.006040059,0.000811141,0.0002096913,0.9760549,0.0003715993,0.00001086108,0.001104487],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02127497,"threshold_uncertainty_score":0.1048169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1396753042356659,"score_gpt":0.4864362466039568,"score_spread":0.346760942368291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}