{"id":"W3128593136","doi":"10.1186/s13063-021-05080-4","title":"Management of Renin-Angiotensin-Aldosterone System blockade in patients admitted to hospital with confirmed coronavirus disease (COVID-19) infection (The McGill RAAS-COVID- 19): A structured summary of a study protocol for a randomized controlled trial","year":2021,"lang":"en","type":"article","venue":"Trials","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; University of Alberta; Canadian VIGOUR Centre; Jewish General Hospital; McGill University; McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; National Heart, Lung, and Blood Institute; McGill University; Alberta Innovates; Amarin Pharma; European Society of Cardiology; Amarin Corporation; McGill University Health Centre","keywords":"Medicine; Discontinuation; Randomized controlled trial; Clinical endpoint; Clinical trial; Randomization; Internal medicine; Aliskiren; Coronavirus disease 2019 (COVID-19); Renin–angiotensin system; Intensive care medicine; Disease; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00933064,0.0004464387,0.00552514,0.0003617353,0.0001678197,0.00002217314,0.0002119724,0.0001233207,0.00005615979],"category_scores_gemma":[0.1649454,0.0002534549,0.0009805685,0.000777606,0.000259554,0.00005334716,0.0002890717,0.0002258516,0.000001471667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006397371,"about_ca_system_score_gemma":0.001469908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007989323,"about_ca_topic_score_gemma":0.0002103017,"domain_scores_codex":[0.9891657,0.004581201,0.003534142,0.0008039842,0.001437556,0.0004774707],"domain_scores_gemma":[0.9737444,0.02192108,0.001724101,0.0008950887,0.0009555453,0.0007597891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9806791,0.003886203,0.006809538,0.002450081,0.004259629,0.0002179312,0.0004313671,0.0001900478,0.00009181027,0.00004134959,0.0002525558,0.0006903809],"study_design_scores_gemma":[0.9712844,0.00862818,0.0133453,0.0007725068,0.003272266,5.733122e-7,0.0002303995,0.0001304836,0.0001698463,0.00006236609,0.001871109,0.0002324971],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"empirical","genre_scores_codex":[0.3175465,0.00001926239,0.0003636836,0.003939319,0.0002152407,0.6775518,0.0002965122,0.00005888802,0.00000872871],"genre_scores_gemma":[0.5900327,0.000005686197,0.0001702032,0.0004058154,0.0001018435,0.4090945,0.00003209362,0.00003062903,0.0001265048],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.2724862,"threshold_uncertainty_score":0.9999918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1396753042356659,"score_gpt":0.4864362466039568,"score_spread":0.346760942368291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}