{"id":"W3128595323","doi":"10.1016/j.molmet.2021.101183","title":"Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis","year":2021,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"National Cancer Institute; National Institutes of Health; Société Francophone du Diabète; National Institute of Allergy and Infectious Diseases; Université Paris Descartes; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale; Conseil Régional, Île-de-France; Canadian Institutes of Health Research; Université de Paris; University of Dundee; Les Laboratories Pierre Fabre; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche; Pfizer","keywords":"AMPK; Glucose homeostasis; Intestinal permeability; AMP-activated protein kinase; Paracellular transport; Gut flora; Protein kinase A; Barrier function; Ex vivo; Homeostasis; Cell biology; Biology; Endocrinology; Chemistry; Internal medicine; In vivo; Kinase; Immunology; Insulin resistance; Biochemistry; Diabetes mellitus; Permeability (electromagnetism); Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002086876,0.0008296481,0.0003917972,0.0004113094,0.000177715,0.000381369,0.0003460144,0.0005537735,0.002773301],"category_scores_gemma":[0.0002070477,0.0003242955,0.0004047027,0.0002269165,0.0006606533,0.0005036209,0.0003333967,0.001296022,0.0006414714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000303093,"about_ca_system_score_gemma":0.0002418212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002429309,"about_ca_topic_score_gemma":0.0003844471,"domain_scores_codex":[0.9997128,0.0000371499,0.00003938778,0.00008513483,0.0000634109,0.00006203711],"domain_scores_gemma":[0.9995493,0.00004249092,0.0002095164,0.00004418551,0.00002331664,0.0001311116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005312162,0.00005476639,0.0002768855,0.00006613627,0.000007961092,0.0000504155,0.00001037299,0.00006989028,0.9982444,0.00006720404,0.00002603346,0.0005946711],"study_design_scores_gemma":[0.00009947493,0.001230326,0.01193911,0.0000375603,0.0000662986,0.0005721154,0.00010948,0.00122047,0.9818692,0.0001216908,0.002720461,0.00001379682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922296,0.001317765,0.00421901,0.0002537718,0.00009785208,0.00004006626,0.0007477493,0.0001788918,0.0009153617],"genre_scores_gemma":[0.9918189,0.001211323,0.00334176,0.0001435812,0.00001928277,0.00008092811,0.0007017973,0.00007918032,0.002603216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002773301,"threshold_uncertainty_score":0.009277642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0109694386189879,"score_gpt":0.2437795438156651,"score_spread":0.2328101051966772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}