{"id":"W3128620152","doi":"10.1016/j.celrep.2021.108790","title":"Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Western University; Université de Montréal; Robarts Clinical Trials; Héma-Québec; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Canada Excellence Research Chairs, Government of Canada; Fondation du CHUM; Canada Foundation for Innovation; Ministère de l'Économie, de l’Innovation et des Exportations du Québec; Canadian Institutes of Health Research; Mitacs","keywords":"Antibody; Neutralization; Convalescent plasma; Isotype; Immunology; Immunoglobulin G; Coronavirus disease 2019 (COVID-19); Neutralizing antibody; Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virus; Immunoglobulin M; Medicine; Monoclonal antibody; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006430279,0.0001334535,0.0003915202,0.0001113971,0.00003128611,0.00001281602,0.000106141,0.0001035563,0.00000533076],"category_scores_gemma":[0.0002262937,0.0001027999,0.0001628814,0.0003889728,0.0001104395,0.00005254403,0.00008452321,0.0003034293,0.000004549151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006622168,"about_ca_system_score_gemma":0.0005309573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003180745,"about_ca_topic_score_gemma":0.0001344899,"domain_scores_codex":[0.998264,0.0001167844,0.0004781178,0.0003188586,0.000536081,0.00028614],"domain_scores_gemma":[0.9987326,0.0001413999,0.0002461025,0.000690511,0.0001682024,0.00002115747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009768118,0.0005201608,0.08584393,0.0003283588,0.00002337215,0.003106196,0.0006100035,8.110526e-7,0.9072284,0.00002140374,0.0001746513,0.002045069],"study_design_scores_gemma":[0.0006073049,0.0000695335,0.01487008,0.0001440753,0.000033576,0.0002678731,0.0004895647,0.0001007533,0.9651616,0.00008590505,0.01808708,0.00008268659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975304,0.0005281332,0.00000596668,0.0001575321,0.0000997512,0.0003269825,0.000002543862,0.00001356668,0.02356153],"genre_scores_gemma":[0.997213,0.0000161767,0.00004458411,0.002606449,0.00004470116,0.00001525299,0.000003780668,0.00001808011,0.00003799769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07097384,"threshold_uncertainty_score":0.419206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04120773021375276,"score_gpt":0.3258936152511019,"score_spread":0.2846858850373492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}