{"id":"W3128652716","doi":"10.3233/jhd-200448","title":"FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders","year":2021,"lang":"en","type":"review","venue":"Journal of Huntington s Disease","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre hospitalier universitaire de Québec; SickKids Foundation; Université Laval; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Hereditary Disease Foundation; Swiss Cancer Research Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Nuclease; Genetics; Trinucleotide repeat expansion; DNA repair; PMS2; DNA damage; DNA mismatch repair; DNA; Gene; Allele","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002517586,0.0007577722,0.0004664758,0.001805063,0.0002404798,0.0005290076,0.0002886931,0.0004835602,0.001606654],"category_scores_gemma":[0.0002201987,0.0001145891,0.0002790638,0.001154713,0.000266804,0.0006530343,0.0003042482,0.0006090489,0.0009025133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005094463,"about_ca_system_score_gemma":0.0004413838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001491382,"about_ca_topic_score_gemma":0.001540757,"domain_scores_codex":[0.9998784,0.00001544502,0.00001712233,0.00003567346,0.0000373474,0.00001599184],"domain_scores_gemma":[0.9999154,0.00002146898,0.00002116367,0.000002129896,0.00002343025,0.00001635109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001851656,0.0000763104,0.003233572,0.005626603,0.0001205114,0.001218014,0.0001283881,0.0004045185,0.009609142,0.005314644,0.0721458,0.9019374],"study_design_scores_gemma":[0.00001056994,0.0001429714,0.004661197,0.0007444769,0.0001113894,0.009750863,0.00004220922,0.0001239768,0.002480454,0.001168294,0.9807464,0.00001709878],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00109254,0.9952224,0.0004915465,0.0004002576,0.0002804556,0.000007822521,0.00007410464,0.000030167,0.002400743],"genre_scores_gemma":[0.009123341,0.9824212,0.000852977,0.000643222,0.0007916195,0.0000158518,0.0003707403,0.00001202874,0.005769072],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001805063,"threshold_uncertainty_score":0.00537473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01542377421190267,"score_gpt":0.2979099665681835,"score_spread":0.2824861923562809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}