{"id":"W3128845188","doi":"10.1016/j.bbagrm.2021.194688","title":"Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains","year":2021,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Genentech; Priority Academic Program Development of Jiangsu Higher Education Institutions; National Natural Science Foundation of China; Kungliga Tekniska Högskolan; Ontario Genomics Institute; Canada Foundation for Innovation; Wellcome Trust; Genome Canada; Boehringer Ingelheim; McGill University; Janssen Pharmaceuticals; Merck KGaA; Merck; Takeda Pharmaceutical Company; Pfizer","keywords":"Histone; DNA; Chemistry; DNA-binding domain; Transcription factor; Cell biology; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001535508,0.0003927636,0.0004806911,0.0001516728,0.0003105779,0.0005135302,0.0004104673,0.0004804925,0.002026395],"category_scores_gemma":[0.0003256034,0.0002183732,0.0001774479,0.0003080783,0.0002412312,0.0004002397,0.0002393989,0.001071311,0.0003804766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004518825,"about_ca_system_score_gemma":0.0003644241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003626577,"about_ca_topic_score_gemma":0.003531543,"domain_scores_codex":[0.999923,0.000006330654,0.000004145252,0.00001905214,0.00003158443,0.00001582728],"domain_scores_gemma":[0.9999081,0.00002683716,0.0000160216,0.000005833331,0.0000127456,0.00003055465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001397764,0.0001852197,0.005211506,0.0003734895,0.0001154025,0.001573254,0.0002487149,0.00238423,0.9739166,0.001690716,0.004279191,0.008623922],"study_design_scores_gemma":[0.0005628507,0.0003411307,0.07203524,0.00007672049,0.0001138832,0.005100321,0.0005253054,0.04126909,0.8478817,0.001604625,0.03032527,0.0001637135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909566,0.002067563,0.003223474,0.0003691737,0.00006124934,0.00001495192,0.001146632,0.0002124131,0.001947968],"genre_scores_gemma":[0.9897204,0.0008388435,0.003600495,0.0001725495,0.00001559199,0.00002062476,0.002988131,0.00004314524,0.002600247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003626577,"threshold_uncertainty_score":0.00721097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131422374363093,"score_gpt":0.2355094458539307,"score_spread":0.2241952221102998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}