{"id":"W3128874312","doi":"10.1101/gad.347989.120","title":"Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex","year":2021,"lang":"en","type":"article","venue":"Genes & Development","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Austrian Science Fund; Österreichischen Akademie der Wissenschaften; U.S. Department of Energy; European Commission; York University; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; European Proteomics Infrastructure Consortium providing access; Memorial Sloan-Kettering Cancer Center; National Cancer Institute; National Science Foundation","keywords":"Piwi-interacting RNA; Argonaute; Biology; RasiRNA; Gene silencing; Genetics; Cell biology; Heterochromatin; RNA-induced silencing complex; RNA interference; RNA; Chromatin; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002053722,0.0004868985,0.0002015238,0.000336587,0.000435129,0.0006604478,0.0004600182,0.0004309531,0.0008435473],"category_scores_gemma":[0.00009039746,0.0002979906,0.0001960555,0.00007252681,0.0008757589,0.0004730888,0.0002497413,0.0005914898,0.000251951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007589296,"about_ca_system_score_gemma":0.0004347977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005979756,"about_ca_topic_score_gemma":0.000646345,"domain_scores_codex":[0.9998819,0.00001267834,0.00000818433,0.00003525595,0.00004528387,0.00001670183],"domain_scores_gemma":[0.999953,0.000006856421,0.00001113204,0.000008296754,0.000005291122,0.00001548993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006738689,0.00004961237,0.0006371544,0.00009025718,0.00001329192,0.000261118,0.00007250605,0.0009578984,0.9724754,0.02179053,0.0001052624,0.003479523],"study_design_scores_gemma":[0.0001573201,0.0005139785,0.01389758,0.00003008517,0.00004342672,0.002549645,0.0001945968,0.03385086,0.9203684,0.01946027,0.00888814,0.00004564381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9141347,0.005977321,0.06783065,0.001260232,0.00007471985,0.0001708558,0.0001494224,0.0004750251,0.00992695],"genre_scores_gemma":[0.9893573,0.001208685,0.007245111,0.00004988273,0.00002160043,0.0000509598,0.00006659684,0.000009995353,0.001989909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008435473,"threshold_uncertainty_score":0.005506456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04691599115692315,"score_gpt":0.2278676794304242,"score_spread":0.180951688273501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}