{"id":"W3128874312","doi":"10.1101/gad.347989.120","title":"Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex","year":2021,"lang":"en","type":"article","venue":"Genes & Development","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Austrian Science Fund; Österreichischen Akademie der Wissenschaften; U.S. Department of Energy; European Commission; York University; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; European Proteomics Infrastructure Consortium providing access; Memorial Sloan-Kettering Cancer Center; National Cancer Institute; National Science Foundation","keywords":"Piwi-interacting RNA; Argonaute; Biology; RasiRNA; Gene silencing; Genetics; Cell biology; Heterochromatin; RNA-induced silencing complex; RNA interference; RNA; Chromatin; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000797086,0.0001009443,0.0001219864,0.000003809647,0.0002198473,0.00002065455,0.0001659187,0.00003834325,0.000791471],"category_scores_gemma":[0.00002303338,0.00003790362,0.0000627453,0.0002994667,0.00004845585,0.00002629591,0.0000829011,0.00004522596,0.00002936315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001869818,"about_ca_system_score_gemma":0.00008047754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000570975,"about_ca_topic_score_gemma":0.0002890989,"domain_scores_codex":[0.9990495,0.00005640411,0.0002675792,0.0001946347,0.0002577162,0.0001741085],"domain_scores_gemma":[0.9996188,0.00009339315,0.00007369373,0.00005526338,0.0001218155,0.00003708344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000003097692,0.00006602538,0.002415948,0.000005846469,0.00003776212,0.000004362632,0.00058382,0.0002579395,0.982766,0.001388376,0.00004717534,0.01242368],"study_design_scores_gemma":[0.000112727,0.00002692113,0.5869028,0.00001724071,0.00001511548,0.00001367204,0.0006012915,0.00009892346,0.1862966,0.00038509,0.2253739,0.0001556877],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955648,0.001085882,0.0001621373,0.002018954,0.0001355627,0.0001130956,0.00002382516,0.00002177896,0.0008739891],"genre_scores_gemma":[0.9949653,0.0001360538,0.00392011,0.0004533002,0.00005515708,0.00002426757,0.0002709794,9.01994e-7,0.0001739717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7964694,"threshold_uncertainty_score":0.8666053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04691599115692315,"score_gpt":0.2278676794304242,"score_spread":0.180951688273501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}