{"id":"W3128892126","doi":"10.3390/biology10020125","title":"A Multifocal Pediatric Papillary Thyroid Carcinoma (PTC) Harboring the AGK-BRAF and RET/PTC3 Fusion in a Mutually Exclusive Pattern Reveals Distinct Levels of Genomic Instability and Nuclear Organization","year":2021,"lang":"en","type":"article","venue":"Biology","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo; University of Manitoba; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; CancerCare Manitoba Foundation","keywords":"Biology; Thyroid carcinoma; Genome instability; Chromatin; Cancer research; Comparative genomic hybridization; Fusion gene; Pathology; Genetics; Thyroid; DNA damage; Gene; Genome; DNA; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001206493,0.0004952033,0.0003780415,0.0006559051,0.00041627,0.0002179705,0.0002191192,0.0005256244,0.0008429161],"category_scores_gemma":[0.0004482261,0.0002856598,0.0002602611,0.0005367637,0.0004477241,0.0002408244,0.0003563189,0.0003262581,0.000211561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004152875,"about_ca_system_score_gemma":0.0004240244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002712041,"about_ca_topic_score_gemma":0.00388006,"domain_scores_codex":[0.9998302,0.00001220477,0.0000135888,0.00006127713,0.00004100266,0.0000416573],"domain_scores_gemma":[0.9996731,0.00008910731,0.00008754314,0.00002531718,0.00002987922,0.00009492791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006558144,0.00009048507,0.2979276,0.0002617898,0.00006727385,0.2881943,0.0008086183,0.0006543802,0.3958381,0.0007070603,0.0002963785,0.01449828],"study_design_scores_gemma":[0.00002278729,0.0006180641,0.3793446,0.00000850022,0.00009122785,0.5852799,0.0003735768,0.001095603,0.03183042,0.0001682289,0.001141659,0.00002532176],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998546,0.0002399745,0.0008105498,0.00002083325,0.000002129142,0.00001135958,0.00008981861,0.00002920503,0.0002501096],"genre_scores_gemma":[0.9990711,0.0001143382,0.0005994111,0.000008638997,0.000004101205,0.000005026996,0.00009168462,0.00000606264,0.00009953458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002712041,"threshold_uncertainty_score":0.005392432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01611811493477596,"score_gpt":0.2461705899144487,"score_spread":0.2300524749796727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}