{"id":"W3128892126","doi":"10.3390/biology10020125","title":"A Multifocal Pediatric Papillary Thyroid Carcinoma (PTC) Harboring the AGK-BRAF and RET/PTC3 Fusion in a Mutually Exclusive Pattern Reveals Distinct Levels of Genomic Instability and Nuclear Organization","year":2021,"lang":"en","type":"article","venue":"Biology","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo; University of Manitoba; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; CancerCare Manitoba Foundation","keywords":"Biology; Thyroid carcinoma; Genome instability; Chromatin; Cancer research; Comparative genomic hybridization; Fusion gene; Pathology; Genetics; Thyroid; DNA damage; Gene; Genome; DNA; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001463717,0.0001311642,0.0003155133,0.00005184165,0.00006979301,0.000008203377,0.00004770295,0.0001079742,0.00006682271],"category_scores_gemma":[0.0001751217,0.00009208337,0.00002925185,0.0001665459,0.00009719003,0.00002686261,0.0002099719,0.0001126574,0.000001894378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008522122,"about_ca_system_score_gemma":0.00009166321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002205884,"about_ca_topic_score_gemma":0.0001439612,"domain_scores_codex":[0.998974,0.0001612061,0.0002921217,0.0003472991,0.00006067014,0.0001646632],"domain_scores_gemma":[0.9993365,0.0001790037,0.0001103998,0.0002329675,0.00007928163,0.0000618443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004888536,0.00011231,0.9286593,0.00009383461,0.00001989512,0.00004853782,0.001272926,3.905351e-7,0.06375254,0.00007192785,0.00001117613,0.005908324],"study_design_scores_gemma":[0.00161749,0.0003273126,0.9961033,0.00002829697,0.00007790818,0.00005227683,0.0003317397,0.00003627454,0.001217302,0.00005740698,0.00006707529,0.0000836264],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934367,0.005186523,0.00001724551,0.0008390655,0.00007382841,0.0003383243,0.00005979328,0.00001280979,0.00003572615],"genre_scores_gemma":[0.9978874,0.001626606,0.00008870815,0.0002141525,0.0001158357,0.00001208482,0.00003104673,0.00001759371,0.00000653639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06744403,"threshold_uncertainty_score":0.3755051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01611811493477596,"score_gpt":0.2461705899144487,"score_spread":0.2300524749796727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}