{"id":"W3128898014","doi":"10.26443/mjm.v3i2.546","title":"Human Germline Gene Therapy","year":2020,"lang":"en","type":"article","venue":"McGill Journal of Medicine","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University","keywords":"Medicine; Germline; Genetic enhancement; Gene; Computational biology; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002142752,0.00008550003,0.0001604119,0.00002622271,0.00006140997,0.000002135019,0.0001287024,0.00005534012,0.00006327627],"category_scores_gemma":[0.0000651465,0.00005676732,0.00006503483,0.00006158579,0.00006485491,0.000001582194,0.00002530275,0.00009963898,0.000002504565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004108329,"about_ca_system_score_gemma":0.00001298918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001983565,"about_ca_topic_score_gemma":2.87157e-7,"domain_scores_codex":[0.9992915,0.00002896031,0.0002882295,0.0001335685,0.0001650854,0.00009269189],"domain_scores_gemma":[0.9994019,0.000001828531,0.0001916997,0.0001081517,0.0001724489,0.0001240104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001076444,0.00002510052,0.0001308787,0.000004352779,0.00005094431,0.0000136382,0.00002669858,0.00004428502,0.9785614,0.00002432224,0.01571507,0.005295692],"study_design_scores_gemma":[0.001689351,0.004146522,0.002145291,0.00001355102,0.0000225193,0.0001779228,0.00004480231,0.000007693393,0.4276874,0.00004974183,0.5639309,0.00008429436],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736825,0.005675189,0.0006783619,0.01874785,0.0003024802,0.00007105074,0.000003597885,0.00000440992,0.0008345746],"genre_scores_gemma":[0.9891704,0.001866061,0.0003282442,0.004844993,0.003535471,4.081093e-7,0.000007056222,0.00001415275,0.000233213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.550874,"threshold_uncertainty_score":0.2314904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04473327754538858,"score_gpt":0.2999790976403391,"score_spread":0.2552458200949506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}