{"id":"W3128906107","doi":"10.1139/bcb-2020-0570","title":"Cetrimonium bromide promotes the clearance of lipids by activating the TFEB-mediated autophagosome–lysosome pathway in hepatic cells","year":2021,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Tianjin Municipal Education Commission; University of Manchester","keywords":"TFEB; Autophagy; Lysosome; Cell biology; mTORC1; Autophagosome; Mechanistic target of rapamycin; Chemistry; PI3K/AKT/mTOR pathway; Biogenesis; Biology; Biochemistry; Signal transduction; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001858405,0.0002999302,0.0004899344,0.0002360876,0.0001581951,0.0002433957,0.0001542496,0.0003272497,0.001503516],"category_scores_gemma":[0.0001584883,0.0001279668,0.0003186317,0.000220599,0.0001985025,0.0002102949,0.0001713058,0.0006029403,0.000415962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003167252,"about_ca_system_score_gemma":0.0004112622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00171363,"about_ca_topic_score_gemma":0.002097111,"domain_scores_codex":[0.9998839,0.00002610721,0.00001977297,0.00001733274,0.00002529071,0.00002757303],"domain_scores_gemma":[0.9999133,0.00001601435,0.00002109198,0.00001181015,0.00001572555,0.0000219599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006083305,0.0000802752,0.0001323294,0.0001050066,0.000008708204,0.00008978915,0.0000173959,0.00007337048,0.9962973,0.00005492617,0.0001417241,0.002390931],"study_design_scores_gemma":[0.00005791643,0.0004283001,0.001296212,0.000006011404,0.00001430256,0.0001061913,0.0000130109,0.0005967167,0.9958187,0.00001892421,0.00164028,0.000003551856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878036,0.005791285,0.00257279,0.0003741967,0.0001356481,0.00005474619,0.0004463477,0.0002263413,0.002595063],"genre_scores_gemma":[0.991917,0.002040728,0.002007295,0.0001519713,0.00003019347,0.0000424082,0.000409822,0.00002494276,0.003375855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00171363,"threshold_uncertainty_score":0.005029798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006694418427370933,"score_gpt":0.2281784971677503,"score_spread":0.2214840787403794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}