{"id":"W3128928797","doi":"10.1210/clinem/dgab056","title":"Monogenic Causes in the Type 1 Diabetes Genetics Consortium Cohort: Low Genetic Risk for Autoimmunity in Case Selection","year":2021,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital","funders":"Fondation de l'Hôpital de Montréal pour enfants; Children's Hospital Foundation; Canadian Institutes of Health Research; HSBC Bank USA","keywords":"Autoantibody; Exome sequencing; Autoimmunity; Haplotype; Medicine; Genetic testing; Type 2 diabetes; Cohort; Diabetes mellitus; Type 1 diabetes; Genetics; Exome; HNF1A; Immunology; Biology; Internal medicine; Genotype; Mutation; Endocrinology; Antibody; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003555064,0.0005166237,0.0005228661,0.001604357,0.001010695,0.001056622,0.000988887,0.001034105,0.003102064],"category_scores_gemma":[0.01527783,0.0002340412,0.0004248409,0.00106267,0.0007713925,0.0005513298,0.0008863177,0.0005452418,0.0003831793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002661689,"about_ca_system_score_gemma":0.0006289863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003172989,"about_ca_topic_score_gemma":0.002968371,"domain_scores_codex":[0.9972249,0.001212893,0.0001905522,0.00073929,0.0003977336,0.0002345382],"domain_scores_gemma":[0.9953577,0.002120725,0.00108969,0.0006746404,0.0002459566,0.0005111843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002689263,0.00003749163,0.9941333,0.0000134287,0.00007239076,0.001679636,0.0001295774,0.0001293741,0.0007321105,0.0001173731,0.0002184409,0.002467965],"study_design_scores_gemma":[0.0001110619,0.0002773415,0.9793862,0.00004514149,0.0002926158,0.01435721,0.0003720169,0.002914561,0.000825341,0.0007423313,0.000654607,0.00002164461],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975671,0.000311274,0.0009710101,0.0001856983,0.00001590377,0.00003917407,0.0001582984,0.00001852097,0.0007331159],"genre_scores_gemma":[0.9990078,0.00006236397,0.0005623696,0.0000688237,0.00002294748,0.00002741309,0.0001576659,0.000007008945,0.00008364583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003555064,"threshold_uncertainty_score":0.01880115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04784651330276499,"score_gpt":0.3629032551863928,"score_spread":0.3150567418836279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}