{"id":"W3128946477","doi":"10.1101/2021.02.02.429298","title":"Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Medical Research Council; Canadian Institutes of Health Research; Science and Engineering Research Board; The Wellcome Trust DBT India Alliance; Department of Science and Technology, Ministry of Science and Technology, India; Department of Biotechnology, Ministry of Science and Technology, India; Wellcome Trust; Lady Tata Memorial Trust; Indian Institute of Technology Kanpur; National Health and Medical Research Council; Japan Agency for Medical Research and Development","keywords":"G protein-coupled receptor; Heterotrimeric G protein; Receptor; Arrestin; Transmembrane protein; Cell biology; Biology; G protein; Functional selectivity; Neuroscience; Transmembrane domain; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001493228,0.000211969,0.0001905657,0.0001472623,0.0001941098,0.0003683961,0.0003002766,0.0002970508,0.001516709],"category_scores_gemma":[0.0001629047,0.0001002554,0.0002387544,0.0001187737,0.0002434851,0.0002370157,0.0002755065,0.0004550928,0.000467214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004331869,"about_ca_system_score_gemma":0.0001844026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005536993,"about_ca_topic_score_gemma":0.0006713073,"domain_scores_codex":[0.9997497,0.00003417265,0.00001429036,0.00006817381,0.00008044152,0.00005319046],"domain_scores_gemma":[0.99989,0.00001674825,0.00004202647,0.00001072082,0.00001810602,0.00002229664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004137895,0.000007880533,0.0003771051,0.00003473498,0.000005368775,0.00007458781,0.00001369638,0.0001347744,0.9981487,0.0004806542,0.00004444574,0.0006367257],"study_design_scores_gemma":[0.00001274453,0.0001715455,0.009611218,0.00001576161,0.00001993404,0.0009389657,0.0001129398,0.004737261,0.9784986,0.0004073594,0.005458165,0.00001554272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893109,0.001552391,0.00594788,0.0001349352,0.00003356775,0.0000220787,0.0003507354,0.00006129743,0.002586275],"genre_scores_gemma":[0.9957094,0.0006432922,0.00232714,0.0001198145,0.000009040569,0.00001106557,0.0002013017,0.00001083159,0.00096808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001516709,"threshold_uncertainty_score":0.005073845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01511924223217496,"score_gpt":0.2189595090084483,"score_spread":0.2038402667762733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}