{"id":"W3128946677","doi":"10.3389/fgene.2020.627673","title":"Targeted Gene Editing in Porcine Spermatogonia","year":2021,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Transcription activator-like effector nuclease; Genome editing; CRISPR; Biology; Germline; Zinc finger nuclease; Cas9; Homology directed repair; Gene; Transgene; Computational biology; Genetics; Stem cell; Gene targeting; Genetic enhancement; DNA repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004093013,0.000236492,0.0002065696,0.000187133,0.0001690209,0.0002895678,0.0002187143,0.0003743835,0.001010086],"category_scores_gemma":[0.0002065623,0.000150673,0.0003400584,0.0001088403,0.000220472,0.0001501717,0.0002801936,0.0003878107,0.000413138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001560938,"about_ca_system_score_gemma":0.0002995909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003133334,"about_ca_topic_score_gemma":0.000514569,"domain_scores_codex":[0.9997419,0.00006008071,0.0000303914,0.00007506186,0.00005969947,0.00003293012],"domain_scores_gemma":[0.9998646,0.00003752199,0.00003653696,0.00002683011,0.00001460661,0.00001983276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000221821,0.000009961709,0.00008619928,0.0000513647,0.000004916832,0.00007404556,0.00002405214,0.0001071222,0.9969757,0.0002568967,0.00004098296,0.00234667],"study_design_scores_gemma":[0.0000221326,0.0005550651,0.002067317,0.00001817955,0.00003101277,0.0007083045,0.00003608481,0.001108266,0.9833888,0.0001495883,0.01190424,0.00001104801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8732902,0.003996624,0.1093461,0.0003194987,0.0004040306,0.0004187593,0.001179118,0.00077977,0.01026588],"genre_scores_gemma":[0.9550988,0.002126608,0.03541635,0.0001827238,0.00003146552,0.000133116,0.001201246,0.0001239918,0.005685825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001010086,"threshold_uncertainty_score":0.003379107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004172038652041871,"score_gpt":0.249658796031368,"score_spread":0.2454867573793262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}