{"id":"W3128946677","doi":"10.3389/fgene.2020.627673","title":"Targeted Gene Editing in Porcine Spermatogonia","year":2021,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Transcription activator-like effector nuclease; Genome editing; CRISPR; Biology; Germline; Zinc finger nuclease; Cas9; Homology directed repair; Gene; Transgene; Computational biology; Genetics; Stem cell; Gene targeting; Genetic enhancement; DNA repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001177722,0.0001574782,0.0001868102,0.00009350273,0.00002203944,0.0000164314,0.0001424418,0.0001552808,0.00001708729],"category_scores_gemma":[0.00006636733,0.0001908899,0.00005306785,0.0002436166,0.00002955826,0.000001932077,0.0001107246,0.0001330994,0.000002867179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002764186,"about_ca_system_score_gemma":0.00007358927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005806939,"about_ca_topic_score_gemma":0.00006971935,"domain_scores_codex":[0.9988712,0.00003758941,0.0002867369,0.0003457532,0.0001126818,0.0003460039],"domain_scores_gemma":[0.9995219,0.00000348467,0.00003413357,0.0003228165,0.00004729396,0.00007040617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001984513,0.0000697384,0.3141317,0.00003655431,0.00002924188,0.0001298247,0.0001417248,0.01820046,0.6530074,0.000006110745,0.008719655,0.005507687],"study_design_scores_gemma":[0.0009760341,0.00004652119,0.05626391,0.0000262096,0.000009555778,0.00004095574,0.000337769,0.004623043,0.9095877,0.00008530817,0.02770306,0.0002998823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9320436,0.02057604,0.04513618,0.0001331188,0.001334921,0.0001209631,0.0000159292,0.00001164536,0.000627657],"genre_scores_gemma":[0.9333374,0.001655777,0.0638082,0.0001730283,0.0004298021,0.00001190106,0.000184461,0.00003646377,0.0003629911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2578678,"threshold_uncertainty_score":0.7784266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004172038652041871,"score_gpt":0.249658796031368,"score_spread":0.2454867573793262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}