{"id":"W3128947369","doi":"10.1016/j.biopsych.2021.01.011","title":"Reward Processing in Novelty Seekers: A Transdiagnostic Psychiatric Imaging Biomarker","year":2021,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Neural and Behavioral Psychology Studies","field":"Neuroscience","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Holland Bloorview Kids Rehabilitation Hospital","funders":"National Institute of Biomedical Imaging and Bioengineering; Fondation pour la Recherche Médicale; National Institute of Mental Health; Horizon 2020; Medical Research Council; National Institute on Aging; Beijing Municipal Science and Technology Commission; Sixth Framework Programme; Seventh Framework Programme; National Institutes of Health; National Institute of General Medical Sciences; Fondation de France; Bundesministerium für Bildung und Forschung; National Natural Science Foundation of China; EU Joint Programme – Neurodegenerative Disease Research; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; European Commission; King’s College London; Foundation for the National Institutes of Health; Deutsche Forschungsgemeinschaft; King's College London; Science Foundation Ireland; National Science Foundation","keywords":"Major depressive disorder; Psychology; Schizophrenia (object-oriented programming); Novelty; Novelty seeking; Neuroimaging; Attention deficit hyperactivity disorder; Bipolar disorder; Clinical psychology; Psychiatry; Dysfunctional family; Prefrontal cortex; Mood; Cognition; Temperament","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000410743,0.0003101631,0.0003033948,0.0006148226,0.0003475556,0.0008066038,0.000307264,0.000711749,0.002103889],"category_scores_gemma":[0.002043039,0.0001548779,0.0001648976,0.0002688407,0.0003255693,0.0004637327,0.0003421855,0.0006206178,0.0001345905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000288871,"about_ca_system_score_gemma":0.0002134697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001112945,"about_ca_topic_score_gemma":0.002421298,"domain_scores_codex":[0.9998734,0.00003504353,0.000009751218,0.00002755587,0.00003551926,0.00001863677],"domain_scores_gemma":[0.9992312,0.0002158218,0.0002948097,0.00003691127,0.0000980508,0.000123222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001820426,0.0006429445,0.9017195,0.000162186,0.0002458459,0.001694606,0.0005255278,0.0001696474,0.05809642,0.0005827571,0.000387515,0.03395261],"study_design_scores_gemma":[0.00002369398,0.0004501886,0.9940725,0.00001905122,0.00005825959,0.001972489,0.0002814048,0.0005942801,0.001826361,0.0004545096,0.0002369512,0.0000101802],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974359,0.0005055291,0.000371425,0.0002269948,0.00001575517,0.00001636397,0.00007310783,0.000003867101,0.001351002],"genre_scores_gemma":[0.9986095,0.0002596794,0.0004711762,0.0001100817,0.00003340835,0.0000102528,0.00006007112,0.000002868931,0.0004428852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002103889,"threshold_uncertainty_score":0.007038236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1546530339737463,"score_gpt":0.3765531408570676,"score_spread":0.2219001068833214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}