{"id":"W3128947369","doi":"10.1016/j.biopsych.2021.01.011","title":"Reward Processing in Novelty Seekers: A Transdiagnostic Psychiatric Imaging Biomarker","year":2021,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Neural and Behavioral Psychology Studies","field":"Neuroscience","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Holland Bloorview Kids Rehabilitation Hospital","funders":"National Institute of Biomedical Imaging and Bioengineering; Fondation pour la Recherche Médicale; National Institute of Mental Health; Horizon 2020; Medical Research Council; National Institute on Aging; Beijing Municipal Science and Technology Commission; Sixth Framework Programme; Seventh Framework Programme; National Institutes of Health; National Institute of General Medical Sciences; Fondation de France; Bundesministerium für Bildung und Forschung; National Natural Science Foundation of China; EU Joint Programme – Neurodegenerative Disease Research; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; European Commission; King’s College London; Foundation for the National Institutes of Health; Deutsche Forschungsgemeinschaft; King's College London; Science Foundation Ireland; National Science Foundation","keywords":"Major depressive disorder; Psychology; Schizophrenia (object-oriented programming); Novelty; Novelty seeking; Neuroimaging; Attention deficit hyperactivity disorder; Bipolar disorder; Clinical psychology; Psychiatry; Dysfunctional family; Prefrontal cortex; Mood; Cognition; Temperament","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001735085,0.0003022291,0.0003527859,0.0001351683,0.0002307119,0.0000568963,0.0003071885,0.0001634722,0.0001661245],"category_scores_gemma":[0.0002784115,0.0002205607,0.0001755658,0.001231165,0.0003079365,0.0001523764,0.00009441627,0.0004154423,0.0001254527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000297454,"about_ca_system_score_gemma":0.00008184999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009123269,"about_ca_topic_score_gemma":0.00004083123,"domain_scores_codex":[0.9973792,0.0002510437,0.0004789736,0.001086721,0.0001881504,0.0006159311],"domain_scores_gemma":[0.9993424,0.0001294897,0.0001064968,0.0002685445,0.0000382345,0.0001147888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001485969,0.001236559,0.7865739,0.00004272623,0.00000327574,0.0003022707,0.00008249795,0.000001527969,0.181088,0.0002567806,0.003037356,0.02722646],"study_design_scores_gemma":[0.002194965,0.0001775038,0.9782406,0.0001285572,0.00003806206,0.0004243882,0.0004743754,0.00007506885,0.004003405,0.008357327,0.005081629,0.0008041291],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764375,0.003792375,0.00009930097,0.01397604,0.00203473,0.0002407092,0.00002216947,0.0001979267,0.003199254],"genre_scores_gemma":[0.9915806,0.0002988443,0.0009989798,0.006778339,0.0001757046,0.00004176985,0.000005692328,0.00001792948,0.0001021358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1916667,"threshold_uncertainty_score":0.8994206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1546530339737463,"score_gpt":0.3765531408570676,"score_spread":0.2219001068833214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}