{"id":"W3128976317","doi":"10.26443/mjm.v7i1.635","title":"Gene Therapy For Adenosine Deaminase Deficiency: Successes and Limitations","year":2020,"lang":"en","type":"article","venue":"McGill Journal of Medicine","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital","funders":"","keywords":"Adenosine deaminase deficiency; Medicine; Adenosine deaminase; Genetic enhancement; AMP deaminase; Adenosine; Gene; Severe combined immunodeficiency; Immunology; Pharmacology; Genetics; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01445748,0.0003971722,0.0006686173,0.0007127098,0.0008604836,0.002282804,0.001081949,0.001750513,0.009032955],"category_scores_gemma":[0.008401783,0.0001610248,0.0005204612,0.0005751026,0.002551581,0.0020303,0.001106984,0.001687426,0.002817157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001236068,"about_ca_system_score_gemma":0.002448462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002984703,"about_ca_topic_score_gemma":0.005681695,"domain_scores_codex":[0.9976366,0.0009215816,0.0002694962,0.0002553004,0.0007290001,0.0001880282],"domain_scores_gemma":[0.9884872,0.007579767,0.0006010216,0.0006612757,0.001992273,0.0006785257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001363418,0.0002263157,0.003007151,0.00164447,0.00007720783,0.0003175717,0.0002427719,0.0003683934,0.01366343,0.01739229,0.02180734,0.9398896],"study_design_scores_gemma":[0.0005018552,0.004266681,0.01579447,0.005444302,0.0002555157,0.004961544,0.0009912495,0.001575644,0.03729055,0.02094176,0.9078482,0.0001281914],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05313716,0.6748994,0.0214012,0.09115736,0.005432503,0.0002146966,0.0003612687,0.0004237757,0.1529726],"genre_scores_gemma":[0.3133896,0.5896235,0.02988911,0.01794606,0.005806053,0.0005928946,0.0003460032,0.0003944335,0.04201237],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01445748,"threshold_uncertainty_score":0.07645935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06943388188404537,"score_gpt":0.336677181369188,"score_spread":0.2672432994851426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}