{"id":"W3128977685","doi":"10.1128/mcb.00464-20","title":"SUMOylation- and GAR1-Dependent Regulation of Dyskerin Nuclear and Subnuclear Localization","year":2021,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Government of Canada; McGill University","keywords":"Nucleolus; Biology; SUMO protein; Ribonucleoprotein; Nuclear localization sequence; Cell biology; Cytoplasm; Telomere; Nucleophosmin; Telomerase; Small nuclear ribonucleoprotein; RNA; Genetics; Ubiquitin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000872914,0.0002638268,0.0001749446,0.0001452515,0.0001546741,0.0003489516,0.0001745856,0.0001473764,0.00105924],"category_scores_gemma":[0.00008285423,0.0001298399,0.0001751467,0.0001084633,0.0002377413,0.0001872264,0.000283632,0.0003575786,0.0004521701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004098141,"about_ca_system_score_gemma":0.0001609123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004791175,"about_ca_topic_score_gemma":0.001189444,"domain_scores_codex":[0.9999052,0.000009385676,0.00001161296,0.00002933713,0.00002164947,0.00002273419],"domain_scores_gemma":[0.9998895,0.00001494078,0.00003885767,0.00001465077,0.00001048416,0.00003153296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005513147,0.000008543961,0.0001425821,0.00001111413,0.000001646165,0.00002523345,0.00001000692,0.00004235923,0.9991233,0.0000684457,0.00001386204,0.0004976593],"study_design_scores_gemma":[0.000005619564,0.00003391931,0.005800831,0.000002033009,0.000005349023,0.00008667856,0.0000227048,0.000961428,0.9919832,0.00004371897,0.001051144,0.000003314076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971723,0.0006966646,0.0009043911,0.00004566257,0.00001401733,0.000008811975,0.0002332931,0.00005031681,0.0008745002],"genre_scores_gemma":[0.9959607,0.0003689785,0.0007214353,0.00002886394,0.000003168393,0.00001276778,0.0003767939,0.00002239273,0.002504922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00105924,"threshold_uncertainty_score":0.003543496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005301694643189312,"score_gpt":0.2222848693513566,"score_spread":0.2169831747081673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}