{"id":"W3129014212","doi":"10.1371/journal.ppat.1009289","title":"PspC domain-containing protein (PCP) determines Streptococcus mutans biofilm formation through bacterial extracellular DNA release and platelet adhesion in experimental endocarditis","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculty of Dentistry, University of Toronto; Taipei Medical University; Ministry of Science and Technology, Taiwan; University of Toronto","keywords":"Streptococcus mutans; Biofilm; Microbiology; Adhesion; Chemistry; Extracellular; Endocarditis; DNA; Platelet adhesion; Neutrophil extracellular traps; Bacteria; Biology; Biochemistry; Medicine; Immunology; Inflammation; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001521126,0.0001962697,0.0001793699,0.0003780502,0.0001297246,0.0001797292,0.0001072601,0.0002260306,0.0009849637],"category_scores_gemma":[0.0001808324,0.0001384178,0.0001982178,0.0001708241,0.0002890388,0.0001080186,0.0001692761,0.0004537446,0.0001799019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003066729,"about_ca_system_score_gemma":0.00013804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006122298,"about_ca_topic_score_gemma":0.0005876432,"domain_scores_codex":[0.9997984,0.00004484313,0.00002370565,0.00004000785,0.0000481242,0.00004491482],"domain_scores_gemma":[0.999835,0.00003792224,0.00005312752,0.00001652019,0.00001318728,0.00004408023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008083589,0.00002366378,0.0001970777,0.000008474134,0.000001480366,0.00002432002,0.000009023577,0.00001439247,0.999398,0.00002414929,0.000007708689,0.0002108273],"study_design_scores_gemma":[0.000008961097,0.0003661382,0.01292656,0.0000033164,0.000009382913,0.0002222313,0.00004391386,0.001015894,0.9849978,0.00003232683,0.0003697006,0.000003697887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983109,0.0002125961,0.0009659884,0.00003304807,0.000006326479,0.000009757109,0.0001652202,0.00002352665,0.0002726006],"genre_scores_gemma":[0.997476,0.0001315438,0.0008744788,0.00002338105,0.000003997879,0.00002085995,0.0003356295,0.000009742498,0.001124277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009849637,"threshold_uncertainty_score":0.003295064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.026090026802978,"score_gpt":0.2663793608232918,"score_spread":0.2402893340203138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}