{"id":"W3129022701","doi":"10.1111/bjd.19866","title":"Five‐year efficacy and safety of tildrakizumab in patients with moderate‐to‐severe psoriasis who respond at week 28: pooled analyses of two randomized phase III clinical trials (reSURFACE 1 and reSURFACE 2)*","year":2021,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Mediprobe Research (Canada); University of Toronto","funders":"Manchester Biomedical Research Centre; Merck Sharp and Dohme; Almirall; National Institute for Health and Care Research","keywords":"Medicine; Psoriasis Area and Severity Index; Internal medicine; Randomized controlled trial; Etanercept; Adverse effect; Placebo; Psoriasis; Gastroenterology; Surgery; Dermatology; Rheumatoid arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02820555,0.002424062,0.008983498,0.001953001,0.000469112,0.002464112,0.001009845,0.001844931,0.001824357],"category_scores_gemma":[0.01638981,0.001236355,0.0228483,0.001682063,0.0007592252,0.001573574,0.001150659,0.002002731,0.0002608091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009184693,"about_ca_system_score_gemma":0.0009067644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008233336,"about_ca_topic_score_gemma":0.001902583,"domain_scores_codex":[0.983207,0.0105798,0.00247894,0.001721979,0.001468724,0.0005435543],"domain_scores_gemma":[0.9833404,0.008470572,0.005275346,0.001417677,0.0008166861,0.0006791778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.5557351,0.0007965073,0.03429218,0.005271473,0.3737751,0.00009060647,0.0001404894,0.00182236,0.002275994,0.00009452524,0.0009411541,0.02476462],"study_design_scores_gemma":[0.2239331,0.05834387,0.1962696,0.0007003964,0.5112571,0.0003392647,0.0001938769,0.003410029,0.001881929,0.0004943112,0.002975877,0.0002006242],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8478212,0.1391957,0.00414873,0.0004281961,0.0005075074,0.001527154,0.004496496,0.0002434873,0.001631431],"genre_scores_gemma":[0.9875265,0.007043389,0.001213452,0.0003682387,0.0002751384,0.0007491873,0.002474206,0.00003456854,0.0003154098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02820555,"threshold_uncertainty_score":0.1491669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03811380251253624,"score_gpt":0.3474621905934935,"score_spread":0.3093483880809573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}