{"id":"W3129022701","doi":"10.1111/bjd.19866","title":"Five‐year efficacy and safety of tildrakizumab in patients with moderate‐to‐severe psoriasis who respond at week 28: pooled analyses of two randomized phase III clinical trials (reSURFACE 1 and reSURFACE 2)*","year":2021,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Mediprobe Research (Canada); University of Toronto","funders":"Manchester Biomedical Research Centre; Merck Sharp and Dohme; Almirall; National Institute for Health and Care Research","keywords":"Medicine; Psoriasis Area and Severity Index; Internal medicine; Randomized controlled trial; Etanercept; Adverse effect; Placebo; Psoriasis; Gastroenterology; Surgery; Dermatology; Rheumatoid arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002086326,0.0002546359,0.003432671,0.000254478,0.0001119933,0.00001902981,0.0001630118,0.0003350588,0.0001250852],"category_scores_gemma":[0.002548303,0.0002211428,0.0002994266,0.0002770398,0.0004277612,0.0001297555,0.0001279692,0.0003110206,0.00000308832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003109482,"about_ca_system_score_gemma":0.0002441969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00010747,"about_ca_topic_score_gemma":0.0001342749,"domain_scores_codex":[0.9904222,0.006210133,0.002562948,0.0003742646,0.0001185891,0.0003118397],"domain_scores_gemma":[0.9939816,0.003728353,0.001467197,0.0002216623,0.0005009219,0.0001002565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9233871,0.002040286,0.03555509,0.00006857568,0.005273023,0.001058395,0.0008696148,0.0001558309,0.00688853,0.00003878022,0.001396769,0.02326808],"study_design_scores_gemma":[0.8806459,0.001002571,0.07346814,0.0007029428,0.002170119,0.004545306,0.0002410916,0.0000121191,0.03666042,0.00006870313,0.0001756789,0.0003069509],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841092,0.01443716,0.00009200882,0.0002399572,0.0002513312,0.0005486902,0.0002579435,0.000005947022,0.00005771189],"genre_scores_gemma":[0.9955576,0.003244783,0.0008358851,0.00004665564,0.0000163165,0.000005184913,0.00006089627,0.00001967395,0.0002130279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04274107,"threshold_uncertainty_score":0.901794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03811380251253624,"score_gpt":0.3474621905934935,"score_spread":0.3093483880809573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}