{"id":"W3129042368","doi":"10.21873/anticanres.14811","title":"The Acute Phase Protein Hepcidin Is Cytotoxic to Human and Mouse Myeloma Cells","year":2021,"lang":"en","type":"article","venue":"Anticancer Research","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Acadia University; Dalhousie University","funders":"Research Nova Scotia; Michael Smith Health Research BC; Breast Cancer Society of Canada; Acadia University","keywords":"Hepcidin; Cytotoxic T cell; DNA fragmentation; Cytotoxicity; Innate immune system; Propidium iodide; Chemistry; Antimicrobial peptides; Apoptosis; Biology; Cell biology; Immune system; Immunology; Programmed cell death; Biochemistry; Peptide; In vitro; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006932551,0.0001129613,0.0002059357,0.00009907789,0.000507434,0.0001193092,0.0001529231,0.00005711645,0.0004205021],"category_scores_gemma":[0.0001389101,0.00007941627,0.00004838813,0.000498237,0.0002908156,0.0000568701,0.0001974905,0.0003582152,0.0001772019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003656118,"about_ca_system_score_gemma":0.0002866999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001772054,"about_ca_topic_score_gemma":0.0000861128,"domain_scores_codex":[0.9980186,0.0001518622,0.0001767798,0.0003715133,0.0006953671,0.0005859273],"domain_scores_gemma":[0.9988024,0.00007674622,0.00001742417,0.0005501106,0.0002707932,0.0002825682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002670551,0.0001765933,0.000208895,0.0000762519,0.00003529411,0.0001432317,0.0006668961,6.084146e-8,0.9678458,0.001780996,0.01763667,0.01116227],"study_design_scores_gemma":[0.002143232,0.0003623468,0.001162481,0.00004601779,0.0000306636,0.00001115933,0.0009222826,0.00001499858,0.9381689,0.0002668264,0.05676058,0.0001104521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823156,0.001281898,0.00002839026,0.012537,0.00003690737,0.000867583,0.00002153078,0.00002226485,0.002888858],"genre_scores_gemma":[0.9644472,0.000799754,0.0002725408,0.001108267,0.0001536463,0.0001399146,0.000006885065,0.0000296372,0.03304215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03912391,"threshold_uncertainty_score":0.4604203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06084216288935094,"score_gpt":0.4375884135707318,"score_spread":0.3767462506813808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}