{"id":"W3129042368","doi":"10.21873/anticanres.14811","title":"The Acute Phase Protein Hepcidin Is Cytotoxic to Human and Mouse Myeloma Cells","year":2021,"lang":"en","type":"article","venue":"Anticancer Research","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Acadia University; Dalhousie University","funders":"Research Nova Scotia; Michael Smith Health Research BC; Breast Cancer Society of Canada; Acadia University","keywords":"Hepcidin; Cytotoxic T cell; DNA fragmentation; Cytotoxicity; Innate immune system; Propidium iodide; Chemistry; Antimicrobial peptides; Apoptosis; Biology; Cell biology; Immune system; Immunology; Programmed cell death; Biochemistry; Peptide; In vitro; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002583247,0.0003198756,0.0002112608,0.0003072087,0.00019798,0.0003134314,0.0001396441,0.0003063862,0.002775134],"category_scores_gemma":[0.0001757811,0.00007786271,0.0002719769,0.0002891176,0.0002777811,0.0001573534,0.0001953434,0.0005323401,0.0003534435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003996659,"about_ca_system_score_gemma":0.000282108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009731172,"about_ca_topic_score_gemma":0.000604559,"domain_scores_codex":[0.9997687,0.00004665323,0.00001907267,0.00003956521,0.00008278694,0.00004315792],"domain_scores_gemma":[0.9998264,0.00006075992,0.00002823083,0.00002867382,0.00002722602,0.00002876941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004573377,0.00007627658,0.0004201197,0.00007184133,0.00001495999,0.00009090797,0.00002492546,0.0001245493,0.9960153,0.0001808678,0.0001152455,0.002407675],"study_design_scores_gemma":[0.00006850958,0.0008880112,0.004504522,0.00001093928,0.00003056493,0.0005742296,0.00002817474,0.001140386,0.988761,0.0001074458,0.0038819,0.000004326273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868051,0.003366508,0.005256093,0.0001783068,0.00005377428,0.0000690565,0.0007717366,0.0001149248,0.003384484],"genre_scores_gemma":[0.9921569,0.001012475,0.002031812,0.0000655068,0.00001625412,0.00005770929,0.001583089,0.00001588294,0.003060494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002775134,"threshold_uncertainty_score":0.009283721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06084216288935094,"score_gpt":0.4375884135707318,"score_spread":0.3767462506813808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}