{"id":"W3129105568","doi":"10.1182/bloodadvances.2020002971","title":"Molecular coevolution of coagulation factor VIII and von Willebrand factor","year":2021,"lang":"en","type":"article","venue":"Blood Advances","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Coevolution; Von Willebrand factor; Biology; In silico; Coagulation; Computational biology; Recombinant DNA; Sequence (biology); Gene; Molecular evolution; Genetics; Evolutionary biology; Phylogenetics; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003080522,0.0001827895,0.0002139924,0.0004826857,0.0002488718,0.0004643491,0.0002001663,0.0003700709,0.0005707028],"category_scores_gemma":[0.0006269233,0.0001365078,0.0002083407,0.0003923496,0.0003761696,0.0003466498,0.0003352654,0.000510309,0.0001756692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003522394,"about_ca_system_score_gemma":0.0002651764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006066366,"about_ca_topic_score_gemma":0.0005192764,"domain_scores_codex":[0.9998056,0.00005120961,0.000008943716,0.00006098204,0.00004539335,0.00002784595],"domain_scores_gemma":[0.9998176,0.00005072155,0.00005693605,0.00002655014,0.0000212768,0.000026871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002766118,0.00002870574,0.02105314,0.00006450425,0.00005502245,0.0007145147,0.0002113454,0.002342499,0.9542145,0.004848682,0.00008941915,0.01610099],"study_design_scores_gemma":[0.00005161752,0.00117339,0.2524896,0.00006602674,0.0003294864,0.008063062,0.0005161361,0.04204228,0.647742,0.006438634,0.04099581,0.00009187271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891117,0.0008057402,0.00834407,0.00007305224,0.00001067988,0.00001253888,0.0001196679,0.0000331794,0.001489194],"genre_scores_gemma":[0.9940744,0.0004770805,0.004427622,0.00004317672,0.00001017319,0.000006796841,0.0003068091,0.00001857395,0.0006354401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006066366,"threshold_uncertainty_score":0.002555668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008765449688569122,"score_gpt":0.2588120911024935,"score_spread":0.2500466414139244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}