{"id":"W3129132895","doi":"10.1158/0008-5472.can-20-2511","title":"ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Interreg; National Cancer Institute; Cancer Council South Australia; Medical Research Council; North Dakota Department of Agriculture; Fondation contre le Cancer; Vlaamse regering; KU Leuven; Fonds Wetenschappelijk Onderzoek; Prostate Cancer Foundation of Australia; National Health and Medical Research Council; Commonwealth Scientific and Industrial Research Organisation; Queen's University Belfast; National Institutes of Health; Queen's University; Department of Health and Aged Care, Australian Government; U.S. Department of Defense; European Commission; Prostate Cancer Foundation; Movember Foundation; Australian Government; Dana-Farber Cancer Institute","keywords":"Prostate cancer; Metastasis; Cancer research; Cancer; Androgen receptor; Lipidome; Cancer cell; Prostate; Fatty acid metabolism; Lipid metabolism; Biology; Fatty acid; Chemistry; Internal medicine; Endocrinology; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001534898,0.0003085495,0.0002075464,0.0003081606,0.0002275878,0.0003642522,0.0001772105,0.000322877,0.001219229],"category_scores_gemma":[0.0001134039,0.000116624,0.000313071,0.0003022818,0.000170217,0.0001717731,0.0003761662,0.0003969846,0.0004659022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000617379,"about_ca_system_score_gemma":0.0003271458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001124911,"about_ca_topic_score_gemma":0.001609104,"domain_scores_codex":[0.9998806,0.00001461539,0.00001119996,0.00003314229,0.00003617906,0.00002424328],"domain_scores_gemma":[0.9999202,0.000007632209,0.00002841809,0.000004947422,0.00001734493,0.00002143552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003043722,0.00001263752,0.001605896,0.0001825834,0.00002265716,0.000101564,0.00001460301,0.0002526248,0.9896554,0.0003116776,0.0002589483,0.007277044],"study_design_scores_gemma":[0.00003105654,0.000292097,0.01900604,0.00006049762,0.00007546433,0.0006186466,0.00008695264,0.001705052,0.9429553,0.0003671276,0.03478295,0.00001880362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.917477,0.056548,0.0155622,0.000911831,0.0002389006,0.00008034393,0.004423025,0.0003732823,0.004385506],"genre_scores_gemma":[0.9830456,0.005809622,0.003196951,0.0002751603,0.00002511941,0.00002645185,0.004114665,0.000027745,0.003478788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001219229,"threshold_uncertainty_score":0.004479468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03641418879254042,"score_gpt":0.3957632059585144,"score_spread":0.359349017165974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}