{"id":"W3129132895","doi":"10.1158/0008-5472.can-20-2511","title":"ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Interreg; National Cancer Institute; Cancer Council South Australia; Medical Research Council; North Dakota Department of Agriculture; Fondation contre le Cancer; Vlaamse regering; KU Leuven; Fonds Wetenschappelijk Onderzoek; Prostate Cancer Foundation of Australia; National Health and Medical Research Council; Commonwealth Scientific and Industrial Research Organisation; Queen's University Belfast; National Institutes of Health; Queen's University; Department of Health and Aged Care, Australian Government; U.S. Department of Defense; European Commission; Prostate Cancer Foundation; Movember Foundation; Australian Government; Dana-Farber Cancer Institute","keywords":"Prostate cancer; Metastasis; Cancer research; Cancer; Androgen receptor; Lipidome; Cancer cell; Prostate; Fatty acid metabolism; Lipid metabolism; Biology; Fatty acid; Chemistry; Internal medicine; Endocrinology; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000447124,0.0001372324,0.0002054526,0.00007805384,0.0001300016,0.00007302558,0.0001429962,0.0001174082,0.000514536],"category_scores_gemma":[0.0002631263,0.0001362288,0.00004938871,0.0003302748,0.0002752903,0.0000108799,0.0002473718,0.0003410201,0.000008681927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007054205,"about_ca_system_score_gemma":0.001034192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001423564,"about_ca_topic_score_gemma":0.004218531,"domain_scores_codex":[0.998085,0.000162988,0.000181651,0.0006002426,0.0003061052,0.0006640537],"domain_scores_gemma":[0.9989933,0.00002576183,0.00001732126,0.0003394065,0.0004109146,0.0002132436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002059627,0.00006864175,0.01382008,0.000145386,0.00003152585,0.000006589506,0.0003055923,0.000009206066,0.9100243,0.0001995349,0.06655739,0.008625712],"study_design_scores_gemma":[0.0007001539,0.00004423858,0.005703073,0.00005329469,0.000007259533,0.000009221942,0.0002458717,0.00001499377,0.4937661,0.0001696818,0.4991322,0.0001539654],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8972008,0.09554085,0.00004310584,0.003998774,0.001691888,0.000301471,0.0002466231,0.000009155379,0.0009672837],"genre_scores_gemma":[0.919652,0.0629898,0.000406073,0.001415282,0.00729971,0.0008438916,0.00006250332,0.00005835552,0.007272399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4325748,"threshold_uncertainty_score":0.5633808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03641418879254042,"score_gpt":0.3957632059585144,"score_spread":0.359349017165974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}