{"id":"W3129142660","doi":"10.1038/s41434-021-00227-z","title":"Human MiniPromoters for ocular-rAAV expression in ON bipolar, cone, corneal, endothelial, Müller glial, and PAX6 cells","year":2021,"lang":"en","type":"article","venue":"Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; BC Children's Hospital; University of British Columbia","funders":"Health Canada; Québec Consortium for Drug Discovery; Weston Brain Institute; Government of Canada; Fondation Brain Canada","keywords":"PAX6; Genetic enhancement; Biology; Gene delivery; Muller glia; Retina; Promoter; Stroma; Gene; Molecular biology; Gene expression; Cancer research; Immunology; Stem cell; Cell biology; Genetics; Neuroscience; Immunohistochemistry; Transcription factor; Progenitor cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004585681,0.0007689067,0.0004448939,0.0005526869,0.0003087991,0.00040459,0.0004433321,0.0004134168,0.004765791],"category_scores_gemma":[0.0003910815,0.0004411085,0.0006417349,0.0003612469,0.0003231307,0.0004273256,0.0004694965,0.000829025,0.002555413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003795401,"about_ca_system_score_gemma":0.0004311843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003517009,"about_ca_topic_score_gemma":0.0009928808,"domain_scores_codex":[0.9996369,0.00005679236,0.00005963061,0.00009705087,0.00009732475,0.00005229798],"domain_scores_gemma":[0.999686,0.00006815354,0.00009485799,0.00005651566,0.00004690548,0.00004756817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001221971,0.00002850372,0.0001949509,0.0001183012,0.000009846969,0.00005510861,0.00005109522,0.0001888461,0.9892372,0.0003830477,0.0002632145,0.009347687],"study_design_scores_gemma":[0.00003065526,0.0003956709,0.0009771378,0.00002831525,0.00005153077,0.0004190116,0.00002657367,0.0007430416,0.9697046,0.0000998133,0.02750704,0.00001656388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6971278,0.007784631,0.2688672,0.0003706335,0.0003400808,0.001944249,0.008058822,0.004308561,0.01119803],"genre_scores_gemma":[0.6813457,0.00633313,0.2386323,0.0004525581,0.00009825037,0.001596612,0.02886809,0.001831445,0.04084197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004765791,"threshold_uncertainty_score":0.01594311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01463467848948813,"score_gpt":0.2950902394436656,"score_spread":0.2804555609541775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}