{"id":"W3129142660","doi":"10.1038/s41434-021-00227-z","title":"Human MiniPromoters for ocular-rAAV expression in ON bipolar, cone, corneal, endothelial, Müller glial, and PAX6 cells","year":2021,"lang":"en","type":"article","venue":"Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; BC Children's Hospital; University of British Columbia","funders":"Health Canada; Québec Consortium for Drug Discovery; Weston Brain Institute; Government of Canada; Fondation Brain Canada","keywords":"PAX6; Genetic enhancement; Biology; Gene delivery; Muller glia; Retina; Promoter; Stroma; Gene; Molecular biology; Gene expression; Cancer research; Immunology; Stem cell; Cell biology; Genetics; Neuroscience; Immunohistochemistry; Transcription factor; Progenitor cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001147594,0.0001701751,0.0001637312,0.00003995257,0.00006576432,0.0000278054,0.0000918178,0.0001313306,0.00002563828],"category_scores_gemma":[0.00001042264,0.0001641622,0.00007270993,0.00004875116,0.0000337144,0.000002200816,0.00003862254,0.0000631913,0.000002113012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007877616,"about_ca_system_score_gemma":0.00003033478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008784687,"about_ca_topic_score_gemma":0.00001703752,"domain_scores_codex":[0.9990935,0.0000387144,0.0001721331,0.0003789774,0.00007882244,0.000237897],"domain_scores_gemma":[0.9995469,0.00001240258,0.00003583008,0.0003014927,0.00003744911,0.00006587023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009348439,0.00007488237,0.0002154662,0.00001438583,0.00002406995,0.000007030786,0.00009207804,0.0001663086,0.9937497,0.000006679975,0.001112889,0.004443013],"study_design_scores_gemma":[0.001733804,0.0003685249,0.000652136,0.00001862424,0.000004228019,0.00000622398,0.00004118806,0.00004218379,0.9186049,0.00003147825,0.0783108,0.0001859574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893104,0.007472515,0.002527515,0.00007677281,0.0002104721,0.0002765231,0.00004726497,0.00001069858,0.00006787109],"genre_scores_gemma":[0.9916045,0.00416758,0.002710365,0.0005003067,0.0002720976,0.00005748735,0.0001134022,0.00004764575,0.0005265955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07719791,"threshold_uncertainty_score":0.6694342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01463467848948813,"score_gpt":0.2950902394436656,"score_spread":0.2804555609541775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}