{"id":"W3129146332","doi":"10.3389/fnsyn.2021.622405","title":"Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice","year":2021,"lang":"en","type":"article","venue":"Frontiers in Synaptic Neuroscience","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Université Laval; Università degli Studi di Napoli Federico II","keywords":"Ventral tegmental area; Orexin; Dopaminergic; Internal medicine; Endocrinology; Endocannabinoid system; Nucleus accumbens; Chemistry; Lateral hypothalamus; AM251; Dopaminergic pathways; Mesolimbic pathway; Diacylglycerol lipase; Dopamine; Orexin receptor; Hypothalamus; Neuroscience; Cannabinoid receptor; Receptor; Biology; Antagonist; Neuropeptide; Medicine; Monoacylglycerol lipase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008860943,0.0003561311,0.0005816939,0.0005043066,0.0002468145,0.0001319053,0.001278151,0.00015376,0.00003104659],"category_scores_gemma":[0.007562319,0.0002864505,0.0001489612,0.00382103,0.001611646,0.0004459083,0.0003901948,0.001021678,0.00001743217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001359941,"about_ca_system_score_gemma":0.0003869937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008308104,"about_ca_topic_score_gemma":0.00006564207,"domain_scores_codex":[0.9940926,0.001441829,0.0008231325,0.001281351,0.001212138,0.001148992],"domain_scores_gemma":[0.9974976,0.001043099,0.0002568231,0.000858854,0.0001225408,0.0002210467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000129326,0.000426253,0.008153445,0.00003891911,0.000002591818,0.001034298,0.0002810958,0.0007967535,0.9862542,0.0006197146,0.0004336838,0.001829758],"study_design_scores_gemma":[0.003146721,0.0004385589,0.02298133,0.0001520886,0.00002177632,0.000309488,0.0006319802,0.0900589,0.8774164,0.00209233,0.002111687,0.0006387265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905602,0.0005057442,0.002739803,0.002283085,0.002070688,0.0008137042,0.00006988605,0.00006052836,0.0008963623],"genre_scores_gemma":[0.997473,0.0002576169,0.0001202209,0.001548577,0.00004308148,0.0001629254,0.000005482364,0.00003805133,0.0003510634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1088377,"threshold_uncertainty_score":0.9999588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01965680218192643,"score_gpt":0.2533490973464125,"score_spread":0.2336922951644861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}