{"id":"W3129146332","doi":"10.3389/fnsyn.2021.622405","title":"Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice","year":2021,"lang":"en","type":"article","venue":"Frontiers in Synaptic Neuroscience","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Université Laval; Università degli Studi di Napoli Federico II","keywords":"Ventral tegmental area; Orexin; Dopaminergic; Internal medicine; Endocrinology; Endocannabinoid system; Nucleus accumbens; Chemistry; Lateral hypothalamus; AM251; Dopaminergic pathways; Mesolimbic pathway; Diacylglycerol lipase; Dopamine; Orexin receptor; Hypothalamus; Neuroscience; Cannabinoid receptor; Receptor; Biology; Antagonist; Neuropeptide; Medicine; Monoacylglycerol lipase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478194,0.0006492981,0.0003874759,0.0008616277,0.0002702951,0.0005255034,0.0003242166,0.0004638709,0.001518507],"category_scores_gemma":[0.0001293842,0.0004400289,0.0003970609,0.0002095917,0.000668215,0.0002872265,0.0004616336,0.001248119,0.0002856486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006969141,"about_ca_system_score_gemma":0.0003729858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002218494,"about_ca_topic_score_gemma":0.005450025,"domain_scores_codex":[0.9997093,0.00002572958,0.00002976756,0.0001012704,0.00006843023,0.00006547879],"domain_scores_gemma":[0.9996114,0.0000129324,0.0001780705,0.00001954166,0.00002095379,0.0001571422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002511784,0.00004224326,0.0002846585,0.00001537906,0.000006095715,0.00005254487,0.00001978911,0.00002629016,0.9987711,0.00008276461,0.00001837051,0.000429505],"study_design_scores_gemma":[0.0001837204,0.0008989302,0.06658047,0.00004350552,0.0001003336,0.0008096006,0.0002791262,0.002346586,0.9247192,0.0003665313,0.003639831,0.00003210522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975858,0.0004192808,0.0009407289,0.00009264389,0.00001840188,0.00001838032,0.0004302839,0.0000704362,0.0004239118],"genre_scores_gemma":[0.9904878,0.000715329,0.002923858,0.0001409357,0.00001517408,0.0000999442,0.0005872372,0.0001506619,0.004879153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002218494,"threshold_uncertainty_score":0.005079925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01965680218192643,"score_gpt":0.2533490973464125,"score_spread":0.2336922951644861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}