{"id":"W3129155137","doi":"10.26443/mjm.v6i1.528","title":"Towards an improved AIDS vaccine: Enhancing the MHC Class I and II Antigen presentation of SIV proteins using ubiquitin and HLA-Dm targeting sequences","year":2020,"lang":"en","type":"article","venue":"McGill Journal of Medicine","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Human leukocyte antigen; Immunology; MHC class I; Antigen presentation; Virology; Presentation (obstetrics); Major histocompatibility complex; Antigen processing; Antigen; Immune system; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004605499,0.0003438557,0.0002544144,0.0001598141,0.0001937616,0.0006452089,0.000310395,0.0005196032,0.00239836],"category_scores_gemma":[0.0002503745,0.000129585,0.0002001002,0.00008648397,0.0002690466,0.000562236,0.0003166243,0.0007265433,0.0006892591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003317625,"about_ca_system_score_gemma":0.000410002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000531085,"about_ca_topic_score_gemma":0.000738158,"domain_scores_codex":[0.9999105,0.00002282345,0.000006567288,0.00001370097,0.00002138023,0.0000251608],"domain_scores_gemma":[0.9999304,0.00000901087,0.00001305282,0.000006768902,0.00002064606,0.00002013611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002675861,0.0002724812,0.0007083283,0.0001542589,0.00001814888,0.00007697745,0.00003981354,0.001084125,0.961667,0.00261214,0.000919704,0.03217945],"study_design_scores_gemma":[0.0002188649,0.004599582,0.00354573,0.0001074976,0.0001028865,0.00093193,0.0001592243,0.01436628,0.932384,0.002755401,0.04079742,0.00003125567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9330475,0.0094596,0.04356734,0.003682878,0.0005116177,0.0002803845,0.0002437317,0.0002987021,0.00890824],"genre_scores_gemma":[0.938959,0.005528964,0.04598624,0.001597222,0.0001440423,0.00007962762,0.0003651006,0.00003526197,0.007304606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00239836,"threshold_uncertainty_score":0.008023381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03371923890957176,"score_gpt":0.3112930590973462,"score_spread":0.2775738201877745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}