{"id":"W3129170145","doi":"10.1002/humu.24176","title":"TAOK1 is associated with neurodevelopmental disorder and essential for neuronal maturation and cortical development","year":2021,"lang":"en","type":"article","venue":"Human Mutation","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Medical Research Council; Horizon 2020 Framework Programme; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; European Commission; ZonMw; National Institute for Health and Care Research","keywords":"Biology; Brain development; Neuroscience; Neurodevelopmental disorder; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004867961,0.0001172077,0.00008006193,0.0000222648,0.0002337919,0.00005560433,0.00002721359,0.00005514501,0.0000123776],"category_scores_gemma":[0.00003434095,0.0001183894,0.00001418535,0.00004349505,0.00005415615,0.000006201129,0.00004985048,0.00004416078,6.653992e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007549401,"about_ca_system_score_gemma":0.00007948247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001028759,"about_ca_topic_score_gemma":0.00009311524,"domain_scores_codex":[0.9992526,0.00002911706,0.0001497364,0.0003242118,0.0001077215,0.0001366791],"domain_scores_gemma":[0.9997538,0.00001077291,0.00004971616,0.00005613536,0.00008124285,0.00004832569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001522234,0.0001624229,0.01084439,0.00004791549,0.0001001118,0.00001031263,0.0007123204,0.00002491047,0.9807605,0.0001553802,0.0004137631,0.006615723],"study_design_scores_gemma":[0.001342579,0.0001875342,0.8983395,0.00001174901,0.00002229349,0.00003090741,0.0001743261,0.000158656,0.09806154,0.00007389178,0.001381592,0.0002154168],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976239,0.00009171849,0.001862403,0.0001236402,0.00004134459,0.0001805667,0.00000985677,0.000007612414,0.00005897025],"genre_scores_gemma":[0.9966418,0.0000270944,0.001709547,0.0003475838,0.00001056793,0.00003325297,0.0009301024,0.00001928871,0.0002807705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8874951,"threshold_uncertainty_score":0.4827781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00864035526723875,"score_gpt":0.2367242580986132,"score_spread":0.2280839028313745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}