{"id":"W3129170145","doi":"10.1002/humu.24176","title":"TAOK1 is associated with neurodevelopmental disorder and essential for neuronal maturation and cortical development","year":2021,"lang":"en","type":"article","venue":"Human Mutation","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Medical Research Council; Horizon 2020 Framework Programme; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; European Commission; ZonMw; National Institute for Health and Care Research","keywords":"Biology; Brain development; Neuroscience; Neurodevelopmental disorder; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001534339,0.0008938424,0.0002894767,0.001012018,0.0004501673,0.0002286294,0.0003106819,0.0003880611,0.002056339],"category_scores_gemma":[0.000494719,0.0001098793,0.000287656,0.0007555579,0.0003767081,0.0001494165,0.0003743554,0.0003066697,0.0002409152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003057273,"about_ca_system_score_gemma":0.0003559367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001724834,"about_ca_topic_score_gemma":0.001417176,"domain_scores_codex":[0.9998323,0.00002024868,0.00002596266,0.00006284669,0.00003444217,0.00002415798],"domain_scores_gemma":[0.9997645,0.00004231375,0.0001169765,0.0000139922,0.00001634575,0.00004585936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003113839,0.0001712219,0.2284398,0.0006506831,0.0005384558,0.1144034,0.0006711911,0.00107412,0.6065202,0.002593548,0.00186209,0.03996157],"study_design_scores_gemma":[0.00008310681,0.0004380004,0.6584996,0.0001371098,0.0004657636,0.2010873,0.0003752859,0.002163793,0.1214353,0.00178481,0.01347075,0.00005917784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928662,0.002396208,0.001798465,0.0001376569,0.00003219373,0.00002194488,0.001351237,0.00008742413,0.001308813],"genre_scores_gemma":[0.9959417,0.0009588943,0.001121786,0.0000328932,0.00001871758,0.00001256492,0.0007097284,0.00001925724,0.001184432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002056339,"threshold_uncertainty_score":0.006879091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00864035526723875,"score_gpt":0.2367242580986132,"score_spread":0.2280839028313745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}