{"id":"W3129175901","doi":"10.1172/jci142677","title":"Inhibition of relaxin autocrine signaling confers therapeutic vulnerability in ovarian cancer","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Pregnancy-related medical research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Université de Montréal; University Health Network; University of Toronto; Princess Margaret Cancer Centre; Centre Hospitalier de l’Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Princess Margaret Cancer Foundation; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Autocrine signalling; Relaxin; Cancer research; Ovarian cancer; Cell growth; Biology; Signal transduction; Internal medicine; Cell culture; Cancer; Medicine; Endocrinology; Cell biology; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.004733894,0.0000994876,0.000662747,0.0001584942,0.00002317326,0.000009853649,0.0000733671,0.0002634634,0.0003674595],"category_scores_gemma":[0.01552201,0.00008029272,0.0002217545,0.00051902,0.0003549706,0.0001760674,0.00003271541,0.001597205,0.000003579363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001503537,"about_ca_system_score_gemma":0.002731335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005323262,"about_ca_topic_score_gemma":0.00002684056,"domain_scores_codex":[0.9958512,0.0007812394,0.002188377,0.0001918875,0.000793554,0.0001938042],"domain_scores_gemma":[0.9963048,0.001303005,0.0007578977,0.0002034505,0.001034264,0.0003966236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001531829,0.001262628,0.4244541,0.0006544827,0.0003922159,0.0007182328,0.000812499,0.000670525,0.466373,0.002218044,0.0003681331,0.1005444],"study_design_scores_gemma":[0.01253067,0.001576378,0.5968646,0.01682972,0.0003557677,0.0001232348,0.000327181,0.004321192,0.3271016,0.03931411,0.0004489597,0.0002066158],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845455,0.001990931,0.001069194,0.01147001,0.0003513604,0.0002020215,0.000002301391,0.000007439015,0.000361241],"genre_scores_gemma":[0.9953404,0.001290207,0.001985077,0.0009839893,0.000269356,0.00000528209,0.000008112861,0.00001280657,0.0001047899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1724105,"threshold_uncertainty_score":0.9927707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1768871047395042,"score_gpt":0.4660540834920239,"score_spread":0.2891669787525197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}