{"id":"W3129179838","doi":"10.1001/jamanetworkopen.2020.33004","title":"Assessment of Food and Drug Administration– and European Medicines Agency–Approved Systemic Oncology Therapies and Clinically Meaningful Improvements in Quality of Life","year":2021,"lang":"en","type":"review","venue":"JAMA Network Open","topic":"Economic and Financial Impacts of Cancer","field":"Economics, Econometrics and Finance","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Centre for Applied Research in Cancer Control; Public Health Ontario; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Cancer Society Research Institute; Canadian Centre for Applied Research in Cancer Control","keywords":"Medicine; Quality of life (healthcare); Food and drug administration; Clinical trial; Internal medicine; Off-label use; Oncology; Intensive care medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.006562158,0.0002831335,0.003318383,0.0001031478,0.00004905224,0.0001154208,0.0003722582,0.0002323502,0.0000290789],"category_scores_gemma":[0.0004579498,0.0002741788,0.0001215061,0.0001538267,0.0001715797,0.0002384742,0.0004716973,0.0003141232,9.697279e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008092324,"about_ca_system_score_gemma":0.0005114338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002565102,"about_ca_topic_score_gemma":0.0002754558,"domain_scores_codex":[0.9956454,0.0004206527,0.003061236,0.00059535,0.000039954,0.0002374289],"domain_scores_gemma":[0.9955823,0.00059693,0.00328074,0.0003531552,0.00006047339,0.0001263739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000775345,0.000179598,0.053825,0.009780676,0.0008082069,0.00000577774,0.001028157,0.000003867474,5.422729e-7,0.04797319,0.0007881168,0.8855293],"study_design_scores_gemma":[0.006562985,0.002520453,0.1868238,0.0218982,0.000338554,0.00002384559,0.0009530043,0.0001401889,3.640335e-7,0.008177402,0.7711762,0.001384983],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02667161,0.9589959,0.00006381686,0.0002274602,0.0002651929,0.001096845,0.0001707974,0.000004307066,0.01250404],"genre_scores_gemma":[0.1734747,0.8252426,0.000681294,0.0001870618,0.0001950849,0.00005148352,0.0000368486,0.00002963897,0.0001012457],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8841444,"threshold_uncertainty_score":0.999971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1223510917798982,"score_gpt":0.3910683863848882,"score_spread":0.2687172946049899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}