{"id":"W3129212257","doi":"10.1093/noajnl/vdab033","title":"Malignant transformation of plexiform neurofibroma to MPNST while on MEK inhibitor","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; Memorial University of Newfoundland; University Health Network; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Plexiform neurofibroma; Transformation (genetics); MEK inhibitor; Cancer research; Malignant transformation; Medicine; Dermatology; Neurofibroma; Neurofibromatosis; Pathology; Biology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001124179,0.0002312762,0.000588763,0.0001780675,0.0001034138,0.00001411415,0.0001091954,0.0001133392,0.0001684937],"category_scores_gemma":[0.0002367178,0.0001988118,0.0001655876,0.0004301897,0.0000992856,0.0002555653,0.00004718366,0.0002311962,0.00008088529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004753965,"about_ca_system_score_gemma":0.0002132842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003027984,"about_ca_topic_score_gemma":0.00001642251,"domain_scores_codex":[0.9981133,0.0001357381,0.0005963399,0.0004560852,0.000356057,0.0003425032],"domain_scores_gemma":[0.9986672,0.0003948795,0.0001645481,0.0003733396,0.0001794433,0.0002205536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001224054,0.0005316662,0.001634977,0.0002626892,0.0000231523,0.001193346,0.0004118574,0.00008870364,0.9702769,0.002404895,0.002429336,0.01951845],"study_design_scores_gemma":[0.001433134,0.005031053,0.00571102,0.0001410181,0.0000556017,0.001000252,0.0002999796,0.00003536748,0.7611332,0.0001055394,0.2248946,0.0001592358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779342,0.0003581378,0.00006974475,0.005691195,0.000881742,0.0004879358,0.00006010816,0.00008823759,0.01442867],"genre_scores_gemma":[0.9936433,0.0002416122,0.001133087,0.004552754,0.0001813052,0.00005497845,0.00003800685,0.00003513576,0.0001198036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2224652,"threshold_uncertainty_score":0.8107311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02517092702622442,"score_gpt":0.2981178608107341,"score_spread":0.2729469337845097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}