{"id":"W3129249197","doi":"10.33380/2305-2066-2021-10-1-120-128","title":"Development and Validation of Valganciclovir and its Active Metabolite Ganciclovir Determination in Human Plasma by HPLC-MS/MS Method","year":2021,"lang":"en","type":"article","venue":"Drug development & registration","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Public Health Association","funders":"","keywords":"Valganciclovir; Ganciclovir; Chromatography; High-performance liquid chromatography; Protein precipitation; Chemistry; Pharmacokinetics; Detection limit; Active metabolite; Metabolite; Human cytomegalovirus; Pharmacology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001028269,0.0002298929,0.0004217949,0.0002807821,0.0001649247,0.00006596064,0.0000624441,0.0001340912,0.00005503241],"category_scores_gemma":[0.0001603467,0.0002346268,0.00003245867,0.0004171911,0.00004713235,0.0003474159,0.00007262292,0.0002277354,0.000005615509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002549747,"about_ca_system_score_gemma":0.0006589162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006807717,"about_ca_topic_score_gemma":0.0003280222,"domain_scores_codex":[0.9977289,0.0001519041,0.000712119,0.0005137452,0.0006037351,0.0002895693],"domain_scores_gemma":[0.9990399,0.00007468981,0.0002481155,0.0001662588,0.0003231999,0.0001477653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001972364,0.0003299398,0.004462212,0.0004941745,0.00008411008,0.00004079106,0.009408718,0.000004317892,0.7991685,0.001020558,0.0001801448,0.1846093],"study_design_scores_gemma":[0.001556288,0.00002604834,0.07747889,0.0001303853,0.00003201855,0.00003493397,0.0004306249,0.0005462525,0.8995663,0.00005883521,0.01992039,0.000219053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958946,0.0006458662,0.001055542,0.0002773213,0.00003756133,0.0005572689,0.00001125603,0.00002574808,0.001494797],"genre_scores_gemma":[0.9611082,0.0002268783,0.03579998,0.00005695592,0.00003469958,0.00009069099,0.0004955478,0.00002684283,0.002160224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1843903,"threshold_uncertainty_score":0.9567804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03204984643737607,"score_gpt":0.3349398710299538,"score_spread":0.3028900245925777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}