{"id":"W3129249197","doi":"10.33380/2305-2066-2021-10-1-120-128","title":"Development and Validation of Valganciclovir and its Active Metabolite Ganciclovir Determination in Human Plasma by HPLC-MS/MS Method","year":2021,"lang":"en","type":"article","venue":"Drug development & registration","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Public Health Association","funders":"","keywords":"Valganciclovir; Ganciclovir; Chromatography; High-performance liquid chromatography; Protein precipitation; Chemistry; Pharmacokinetics; Detection limit; Active metabolite; Metabolite; Human cytomegalovirus; Pharmacology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003307777,0.001315149,0.0007827086,0.001536208,0.0006701183,0.0007883087,0.0006959451,0.001935935,0.001327975],"category_scores_gemma":[0.002861276,0.0005578574,0.0007424385,0.0006462024,0.0008328013,0.0004716231,0.0006076791,0.001177451,0.001077543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007750527,"about_ca_system_score_gemma":0.002172267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001595977,"about_ca_topic_score_gemma":0.001788452,"domain_scores_codex":[0.9946516,0.001192865,0.0003922843,0.001079574,0.002497033,0.0001867932],"domain_scores_gemma":[0.99906,0.0002209504,0.0001505745,0.000080842,0.0004349228,0.00005280187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006563878,0.0002701358,0.006138016,0.001048429,0.0001929576,0.000337667,0.0001680962,0.000916538,0.9209265,0.0006829168,0.0009162435,0.06774598],"study_design_scores_gemma":[0.0001601701,0.00184851,0.01177475,0.0002510824,0.00024718,0.002947461,0.0001116233,0.007917961,0.9542064,0.0006258473,0.01978498,0.000123971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3599156,0.05902737,0.552233,0.00155753,0.001272155,0.004155275,0.004745052,0.003448264,0.01364567],"genre_scores_gemma":[0.6129004,0.01487195,0.35526,0.001928808,0.0002878926,0.003605756,0.002750138,0.0001786329,0.008216378],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.003307777,"threshold_uncertainty_score":0.01749337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03204984643737607,"score_gpt":0.3349398710299538,"score_spread":0.3028900245925777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}