{"id":"W312927025","doi":"10.1021/acs.jmedchem.5b00458","title":"Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF","year":2015,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Genome Canada; Wellcome; GlaxoSmithKline; Bayer; Pfizer; Eli Lilly and Company","keywords":"Bromodomain; Ubiquitin ligase; Chemistry; Regulator; Ubiquitin; Computational biology; Cancer research; Cell biology; Biochemistry; Biology; Gene; Epigenetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006468658,0.00009580419,0.0002177362,0.00001638451,0.0000143991,0.000007560839,0.0001689627,0.0001078947,0.000005070605],"category_scores_gemma":[0.00094926,0.00006170701,0.00009625326,0.00006017028,0.0002217072,0.00001065049,0.00007248068,0.0001757385,1.102946e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001524379,"about_ca_system_score_gemma":0.0002212282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003632033,"about_ca_topic_score_gemma":1.052273e-7,"domain_scores_codex":[0.9989493,0.00003118414,0.0004856962,0.00009612428,0.0003360284,0.0001016327],"domain_scores_gemma":[0.9990612,0.00002972496,0.0004735235,0.0001329016,0.0002200484,0.00008263352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002668653,0.00005027136,0.0005563817,0.0000731884,0.00003945527,0.00000421446,0.00008553025,0.000001178176,0.9931933,0.000005539292,0.005281962,0.0004421533],"study_design_scores_gemma":[0.00100456,0.0002091184,0.00005978898,0.0001079047,0.00003518826,0.0001747796,0.0005983356,0.00001389109,0.9954274,0.00006036181,0.002244096,0.00006457021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962448,0.002629242,0.0002325997,0.0003765389,0.00009632145,0.00004578173,0.000006364085,0.000001101695,0.0003672752],"genre_scores_gemma":[0.9984306,0.00009327345,0.0005213381,0.00005763547,0.000774756,0.000001007394,0.000007677409,0.000007835754,0.0001058979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003037867,"threshold_uncertainty_score":0.2516339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01056900249236208,"score_gpt":0.2420632151425982,"score_spread":0.2314942126502361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}