{"id":"W312927025","doi":"10.1021/acs.jmedchem.5b00458","title":"Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF","year":2015,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Genome Canada; Wellcome; GlaxoSmithKline; Bayer; Pfizer; Eli Lilly and Company","keywords":"Bromodomain; Ubiquitin ligase; Chemistry; Regulator; Ubiquitin; Computational biology; Cancer research; Cell biology; Biochemistry; Biology; Gene; Epigenetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001553066,0.0004120529,0.0003464104,0.0003680003,0.0001563842,0.0002052633,0.0003818454,0.0002612436,0.001262592],"category_scores_gemma":[0.0001020552,0.0001476618,0.0002404044,0.0001897775,0.0001400803,0.0001821596,0.0002162834,0.0004748522,0.0004560361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003154564,"about_ca_system_score_gemma":0.0002546209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005087059,"about_ca_topic_score_gemma":0.001185838,"domain_scores_codex":[0.9999324,0.000008134396,0.000004401859,0.00001363524,0.00001791404,0.00002350551],"domain_scores_gemma":[0.9999615,0.000006021912,0.000008680654,0.000003057693,0.000008521983,0.00001220005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002241349,0.0001482443,0.0001593635,0.0001462666,0.00002303195,0.0001541271,0.0000229885,0.0004935195,0.9876814,0.0003470879,0.0003731439,0.01022665],"study_design_scores_gemma":[0.0002653907,0.001861394,0.001762742,0.00001956662,0.00007482077,0.0009107994,0.00001734014,0.002346222,0.9808856,0.00009097125,0.01174655,0.00001856965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9447125,0.01600455,0.02640273,0.0005333511,0.0001145577,0.0005040847,0.001131986,0.0005459872,0.01005036],"genre_scores_gemma":[0.975862,0.006694983,0.009452917,0.000173682,0.00002692862,0.0001559613,0.001049673,0.00002542422,0.006558528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001262592,"threshold_uncertainty_score":0.004223824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01056900249236208,"score_gpt":0.2420632151425982,"score_spread":0.2314942126502361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}