{"id":"W3129352024","doi":"10.1016/j.pnpbp.2021.110289","title":"Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence","year":2021,"lang":"en","type":"review","venue":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":161,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University of Guelph; St. Michael's Hospital","funders":"","keywords":"Anhedonia; Neuroscience; Psychology; Reward system; Nucleus accumbens; Ventral tegmental area; Ventral striatum; Orbitofrontal cortex; Anterior cingulate cortex; Anticipation (artificial intelligence); Neuroimaging; Ventral pallidum; Prefrontal cortex; Dopamine; Cognition; Striatum; Dopaminergic; Basal ganglia; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004602745,0.0009782065,0.00177878,0.001209383,0.0001564765,0.0009837811,0.0008314914,0.0008505434,0.002349819],"category_scores_gemma":[0.0006136321,0.0002144291,0.0004840352,0.00135236,0.0003958775,0.0006916922,0.0005974894,0.001378789,0.0008809016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003914467,"about_ca_system_score_gemma":0.0007487743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001139338,"about_ca_topic_score_gemma":0.002297698,"domain_scores_codex":[0.9999045,0.00001425632,0.00001469256,0.00002590051,0.00003186312,0.000008846212],"domain_scores_gemma":[0.9997782,0.0001199242,0.00003450359,0.000005943143,0.00004152211,0.00001983836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002227798,0.00007505382,0.0003704319,0.02061099,0.0002259724,0.0002109255,0.00003601665,0.000449395,0.00168294,0.001774414,0.01272574,0.9616153],"study_design_scores_gemma":[0.000215334,0.0005389547,0.008605104,0.01785659,0.001486397,0.004239882,0.0002205608,0.0006674309,0.001091477,0.008269676,0.9567079,0.0001007459],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009188825,0.999485,0.00006165139,0.0000806438,0.00005768703,0.000002382252,0.00001546553,0.000002505927,0.0002026992],"genre_scores_gemma":[0.0005565708,0.9990478,0.00009846108,0.00006401696,0.00008375328,0.000002775029,0.00001740602,4.696198e-7,0.0001288199],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002349819,"threshold_uncertainty_score":0.007860959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2099106349996841,"score_gpt":0.4924544076019726,"score_spread":0.2825437726022885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}