{"id":"W3129402656","doi":"10.1038/s41598-021-83630-1","title":"Sensitive protein misfolding cyclic amplification of sporadic Creutzfeldt–Jakob disease prions is strongly seed and substrate dependent","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Canada Research Chairs; University of Toronto","funders":"Université de Montpellier; Agence Nationale de Sécurité du Médicament et des Produits de Santé","keywords":"Prion protein; Biology; In vitro; Valine; Virology; Methionine; Molecular biology; Biochemistry; Disease; Pathology; Amino acid; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002042014,0.0003372882,0.0001940491,0.0002418878,0.0001297743,0.0002589777,0.0001315616,0.0002182306,0.0007797939],"category_scores_gemma":[0.000323038,0.0002125588,0.0001694684,0.0001640981,0.0002098011,0.0001278644,0.0002257958,0.0002921545,0.0002454607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001286584,"about_ca_system_score_gemma":0.00008389374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005015795,"about_ca_topic_score_gemma":0.0007180783,"domain_scores_codex":[0.9997496,0.00006150426,0.00002377273,0.00005334407,0.00007032385,0.00004155915],"domain_scores_gemma":[0.9996561,0.0001041089,0.0000787164,0.00006416482,0.00005486681,0.00004203732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002175395,0.000006195796,0.0003160833,0.000009097465,0.000002526017,0.0000272033,0.000006584468,0.00001203049,0.9993962,0.000006333423,0.000006022285,0.0001898668],"study_design_scores_gemma":[0.000002932285,0.0002322336,0.01922923,0.000003433686,0.00001039396,0.0006557156,0.00001656627,0.0006140399,0.9788648,0.00001974597,0.0003477552,0.000003240857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974626,0.0004722757,0.001499493,0.000009799358,0.000005283464,0.0000149966,0.00009255386,0.00003521905,0.0004076821],"genre_scores_gemma":[0.9980313,0.0001362435,0.001116446,0.00001192185,0.000004750604,0.00001388192,0.0002092421,0.00001073826,0.0004654361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007797939,"threshold_uncertainty_score":0.002608716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01123972644281891,"score_gpt":0.2467558353912938,"score_spread":0.2355161089484749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}