{"id":"W3129436880","doi":"10.22203/ecm.v041a14","title":"Spatiotemporal and functional characterisation of transient receptor potential vanilloid 4 (TRPV4) in the murine intervertebral disc","year":2021,"lang":"en","type":"article","venue":"European Cells and Materials","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Arthritis Society","keywords":"TRPV4; Cell biology; Transient receptor potential channel; Mechanotransduction; Intervertebral disc; Chemistry; Signal transduction; Anatomy; Biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002912937,0.0002967097,0.0003913661,0.0007893239,0.0002448117,0.0004292739,0.0003802523,0.0006464106,0.001270112],"category_scores_gemma":[0.0003254727,0.0003074114,0.0004584802,0.0002314385,0.0004408191,0.0004196767,0.0003293448,0.0006273336,0.0006726303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003741513,"about_ca_system_score_gemma":0.0003030953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007890133,"about_ca_topic_score_gemma":0.0009995627,"domain_scores_codex":[0.9997014,0.0000261288,0.00003093317,0.00008295018,0.00008943403,0.00006905551],"domain_scores_gemma":[0.9997428,0.00002771339,0.0001068341,0.00002810978,0.00004422467,0.00005041809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004537236,0.00000894922,0.0003154014,0.00004284427,0.000001758586,0.00003851514,0.00001528215,0.00004056921,0.9986783,0.00005146032,0.000008973131,0.0007526231],"study_design_scores_gemma":[0.00003596628,0.001115291,0.03763459,0.00004896781,0.00006133306,0.001207963,0.0002102753,0.001034376,0.9529868,0.000190162,0.005457112,0.00001709506],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979668,0.00506604,0.01175263,0.0001356081,0.00003902636,0.00008730097,0.001224831,0.0001342918,0.001892281],"genre_scores_gemma":[0.9723948,0.003165757,0.01543397,0.0001039108,0.00002469196,0.0001655704,0.001523494,0.00005162226,0.007136217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001270112,"threshold_uncertainty_score":0.004248977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01304876576562332,"score_gpt":0.2096335401284725,"score_spread":0.1965847743628492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}